INT305742

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.64
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sort1, Gtf3a) cell differentiation (Sort1) endosome (Sort1)
transport (Sort1) Golgi apparatus (Sort1) endoplasmic reticulum (Sort1)
Anatomy Link Frequency
neuronal 2
Sort1 (Mus musculus)
Gtf3a (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 132 85.92 High High
depression 68 79.68 Quite High
neurotrophin 3 2 70.08 Quite High
sSRI 18 64.56 Quite High
noradrenaline 8 58.72 Quite High
Serotonin 2 55.04 Quite High
monoamine 2 54.64 Quite High
potassium channel 12 24.88 Low Low
antagonist 8 15.44 Low Low
fluoxetine 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 4 95.80 Very High Very High Very High
Neurodegenerative Disease 32 93.60 High High
Depression 68 79.68 Quite High
Disease 6 50.28 Quite High
Mental Disorders 2 47.04 Quite Low
Anxiety Disorder 26 5.00 Very Low Very Low Very Low
Stress 14 5.00 Very Low Very Low Very Low
Shock 6 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interaction between NTSR3/Sortilin and the N-terminal portion of the precursor form of the NGF (pro-NGF) and the brain-derived neurotrophic factor (pro-BDNF) represents a key event in the process that controls neurotrophins-mediated cell survival and death in developing neuronal tissue and post-traumatic neuronal apoptosis [42].
NTSR3 Binding (interaction) of factor in neuronal associated with neurodegenerative disease and death
1) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.32 Pain Relevance 0.44
The interaction between NTSR3/Sortilin and the N-terminal portion of the precursor form of the NGF (pro-NGF) and the brain-derived neurotrophic factor (pro-BDNF) represents a key event in the process that controls neurotrophins-mediated cell survival and death in developing neuronal tissue and post-traumatic neuronal apoptosis [42].
Sortilin Binding (interaction) of factor in neuronal associated with neurodegenerative disease and death
2) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.32 Pain Relevance 0.44

General Comments

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