INT305744

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fst, Creb1) mitochondrion (Creb1) extracellular region (Fst)
DNA binding (Creb1) transcription factor binding (Creb1) cytoplasm (Fst)
Anatomy Link Frequency
hippocampus 1
Fst (Mus musculus)
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 66 99.16 Very High Very High Very High
Hippocampus 9 98.16 Very High Very High Very High
sSRI 9 93.68 High High
depression 34 79.52 Quite High
Pyramidal cell 4 52.60 Quite High
antagonist 4 21.96 Low Low
fluoxetine 16 5.00 Very Low Very Low Very Low
potassium channel 6 5.00 Very Low Very Low Very Low
Raphe 4 5.00 Very Low Very Low Very Low
noradrenaline 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 16 99.44 Very High Very High Very High
Depression 34 79.52 Quite High
Anxiety Disorder 13 8.08 Low Low
Stress 7 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Shock 3 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fast-acting antidepressant potential of spadin, observed in vivo in FST and TST tests, is further confirmed by its ability to activate CREB function and neurogenesis in the adult mouse hippocampus after a subchronic treatment.
FST Positive_regulation (activate) of CREB in hippocampus associated with antidepressant, hippocampus and neurodegenerative disease
1) Confidence 0.12 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.33 Pain Relevance 0.57

General Comments

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