INT305747

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.49
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf, Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf, Bdnf) mitochondrion (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
brain 2
Bdnf (Mus musculus)
Creb1 (Mus musculus)
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 66 100.00 Very High Very High Very High
sSRI 9 91.56 High High
depression 34 80.16 Quite High
Hippocampus 9 75.92 Quite High
Pyramidal cell 4 23.40 Low Low
fluoxetine 16 5.00 Very Low Very Low Very Low
potassium channel 6 5.00 Very Low Very Low Very Low
Raphe 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
noradrenaline 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 16 84.76 Quite High
Depression 34 80.16 Quite High
Anxiety Disorder 13 76.72 Quite High
Stress 7 54.88 Quite High
Disease 3 5.00 Very Low Very Low Very Low
Shock 3 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CREB upregulation activates downstream targets such as the brain-derived growth factor (BDNF) after antidepressant treatment by binding to CRE elements located in the promoter region of the BDNF gene [49].
BDNF gene Binding (binding) of CREB in brain Positive_regulation (activates) of brain-derived growth factor associated with antidepressant
1) Confidence 0.03 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.49 Pain Relevance 0.47

General Comments

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