INT305790

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 17
Disease Relevance 3.01
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

OxP-11D (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 340 96.80 Very High Very High Very High
Inflammatory response 34 61.08 Quite High
rheumatoid arthritis 17 49.48 Quite Low
anesthesia 17 5.00 Very Low Very Low Very Low
isoflurane 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemolysis 34 97.00 Very High Very High Very High
INFLAMMATION 357 96.80 Very High Very High Very High
Atherosclerosis 85 82.52 Quite High
Cardiovascular Disease 68 69.76 Quite High
Inflammatory Bowel Disease 17 51.04 Quite High
Rheumatoid Arthritis 17 49.48 Quite Low
Colitis 17 48.16 Quite Low
Cancer 17 47.40 Quite Low
Diabetes Mellitus 17 46.88 Quite Low
Asthma 17 46.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D-4F and OxP-11D bound these sterols similarly (Table 3).
OxP-11D Binding (bound) of
1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2854715 Disease Relevance 0.15 Pain Relevance 0.03
We used surface plasmon resonance (SPR) to examine binding of OxP-11D to various sterols, oxidized and non-oxidized lipids.
OxP-11D Spec (examine) Binding (binding) of
2) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2854715 Disease Relevance 0.24 Pain Relevance 0.08
Nonetheless, OxP-11D bound oxidized lipids and sterols preferentially, and with much higher affinity than apoA-I.
OxP-11D Binding (bound) of
3) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2854715 Disease Relevance 0.10 Pain Relevance 0.05
Both peptides bound normal and oxidized cholesterol, but OxP-11D did so with higher affinity.
OxP-11D Binding (bound) of
4) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2854715 Disease Relevance 0.15 Pain Relevance 0.04
OxP-11D bound five of the lipids with higher affinity than D-4F, including palmitic acid, 5(S)-HPETE, 12(S)-HPETE, 15(S)-HPETE, 13(S) and 13(S)-HODE.
OxP-11D Binding (bound) of
5) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2854715 Disease Relevance 0.14 Pain Relevance 0.03
OxP-11D binds oxidized lipids and sterols
OxP-11D Binding (binds) of
6) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2854715 Disease Relevance 0.23 Pain Relevance 0.08
OxP-11D binds to cholesterol (Figure 4A) and several oxysterols, including 20(S)-hydroxycholesterol (Figure 4B) and 24(S)-hydroxycholesterol (Figure 4C).
OxP-11D Binding (binds) of
7) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2854715 Disease Relevance 0.16 Pain Relevance 0.03
For example, OxP-11D bound 12(S)-HPETE (hydroperoxyeicosatetraenoic acid) with higher affinity than D-4F, and yet D-4F bound 12(S)-HETE (hydroxyeicosatetraenoic acid) with much higher affinity than OxP-11D.
OxP-11D Binding (bound) of
8) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2854715 Disease Relevance 0.11 Pain Relevance 0.03
Five of the 15 nonsteroid lipids in Table 3 were apparently bound with higher affinity by OxP-11D and ten were bound more effectively by D-4F.
OxP-11D Binding (bound) of
9) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2854715 Disease Relevance 0.14 Pain Relevance 0.04
Binding of some of our peptides to cholesterol, including OxP-11D, was suggested by our early experiments showing that peptides can prevent hemolysis of human RBCs mediated by CDCs in concentration dependent manner (data not shown, separate manuscript in preparation) and we decided to investigate this phenomenon in greater detail.
OxP-11D Binding (Binding) of associated with hemolysis
10) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2854715 Disease Relevance 0.24 Pain Relevance 0.07
For example, OxP-11D bound 12(S)-HPETE (hydroperoxyeicosatetraenoic acid) with higher affinity than D-4F, and yet D-4F bound 12(S)-HETE (hydroxyeicosatetraenoic acid) with much higher affinity than OxP-11D.
OxP-11D Binding (affinity) of
11) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2854715 Disease Relevance 0 Pain Relevance 0
In contrast, based on the KD ratios, the affinity of OxP-11D for 5(S)-HPETE was approximately 57-fold higher than its affinity for arachidonic acid, and its affinity for 12(S)-HPETE was approximately 28.5-fold higher.
OxP-11D Binding (affinity) of
12) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2854715 Disease Relevance 0.13 Pain Relevance 0.06
How do the lipid binding properties of D-4F and OxP-11D compare?
OxP-11D Binding (binding) of
13) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2854715 Disease Relevance 0.19 Pain Relevance 0.10
Similarly, OxP-11D bound 13(S)-HODE (hydroxyoctadecadienoic acid) with higher affinity than D-4F, yet D-4F had greater affinity for 9(S)-HODE.
OxP-11D Binding (bound) of
14) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2854715 Disease Relevance 0 Pain Relevance 0
In surface plasmon resonance binding studies, OxP-11D bound oxidized (phospho)lipids and sterols in much the same manner as D-4F, a widely studied cardioprotective apoA-I-mimetic peptide with anti-inflammatory properties.
OxP-11D Binding (bound) of associated with inflammation
15) Confidence 0.07 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2854715 Disease Relevance 0.34 Pain Relevance 0.17
The ability of OxP-11D to bind oxidized phospholipids and sterols resemble those of D-4F [42].
OxP-11D Binding (bind) of
16) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2854715 Disease Relevance 0.69 Pain Relevance 0.15
The position of oxidation appeared to influence binding affinity, as OxP-11D bound tightly to cholesterol derivatives hydroxylated in positions 20(S)-, 22(S)- and 24(S)-, but not to 25-hydroxycholesterol or 4?
OxP-11D Spec (appeared) Binding (bound) of
17) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2854715 Disease Relevance 0 Pain Relevance 0

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