INT305832

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 14
Disease Relevance 0.49
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Polk) DNA binding (Polk) nucleotidyltransferase activity (Polk)
Anatomy Link Frequency
immune cells 1
T cells 1
Polk (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 266 99.78 Very High Very High Very High
chemokine 280 97.72 Very High Very High Very High
Inflammation 84 62.24 Quite High
Inflammatory mediators 14 5.00 Very Low Very Low Very Low
anesthesia 14 5.00 Very Low Very Low Very Low
halothane 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 28 90.32 High High
Body Weight 42 80.24 Quite High
Eczema 308 71.36 Quite High
Hypersensitivity 98 70.40 Quite High
Rhinitis 42 63.28 Quite High
INFLAMMATION 98 62.24 Quite High
Pressure And Volume Under Development 14 42.72 Quite Low
Injury 14 41.92 Quite Low
Asthma 42 39.68 Quite Low
Respiratory Sounds 14 39.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure of immune cells to DINP
Gene_expression (Exposure) of DINP in immune cells
1) Confidence 0.48 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.06
and IL-17 in the cocultures was not significantly altered by DINP exposure (Figure 4C,D).
Gene_expression (exposure) of DINP
2) Confidence 0.42 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.10
DINP exposure for 24 hr significantly increased the production of TH2 chemokines, TARC/CCL17 (Figure 3A; 100 ?
Gene_expression (exposure) of DINP associated with chemokine
3) Confidence 0.42 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.22
Diisononyl phthalate (DINP) is used in flooring, wire and cable, dip coating, coated fabrics, tubing, shoes, sealants, and artificial leather, and humans may be exposed to DINP by the oral, dermal, and inhalation routes (Kavlock et al. 2002).
Gene_expression (exposed) of DINP
4) Confidence 0.42 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.17 Pain Relevance 0
DINP exposure for 24 hr significantly increased IL-4 production from splenocytes compared with controls (Figure 5A; 10 ?
Gene_expression (exposure) of DINP
5) Confidence 0.42 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.05 Pain Relevance 0.08
IP treatment with DINP did not clearly affect the expression of these cytokines, although DINP tended to decrease IFN-?
Gene_expression (tended) of DINP associated with cytokine
6) Confidence 0.42 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.21
In the presence of GM-CSF (10 ng/mL), BMDCs (1 × 106/mL) were exposed to DINP (0, 0.1, 1, 10, or 100 ?
Gene_expression (exposed) of DINP
7) Confidence 0.42 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.11
(Figure 4C) and IL-17 (Figure 4D) tended to increase in response to DINP exposure in the same manner as IL-4 without significance.
Gene_expression (exposure) of DINP
8) Confidence 0.42 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.13
, and IL-12p40 were < 10 pg/mL, and we observed no effects of DINP (data not shown).
Neg (no) Gene_expression (effects) of DINP
9) Confidence 0.42 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.07 Pain Relevance 0
The levels of IL-4 in the cocultures of T cells and BMDCs exposed to DINP were also increased compared with controls (Figure 4B; 1 ?
Gene_expression (exposed) of DINP in T cells
10) Confidence 0.42 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.20
M DINP, p < 0.01; 0.1 or 100 ?
Gene_expression (0.1) of DINP
11) Confidence 0.42 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.21
, and IL-12p40 were < 10 pg/mL, and we observed no effects of DINP (data not shown).
Neg (no) Gene_expression (effects) of DINP
12) Confidence 0.42 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.20 Pain Relevance 0.07
After DINP exposure, the cells (3–5 × 105) were resuspended in 100 ?
Gene_expression (exposure) of DINP
13) Confidence 0.42 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.16
The DINP solution was sonicated for 3 min using an ultrasonic disrupter (UD-201; TOMY, Tokyo, Japan).
Gene_expression (solution) of DINP
14) Confidence 0.42 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.07

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