INT305840

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccr7) plasma membrane (Ccr7) intracellular (Ccr7)
signal transducer activity (Ccr7)
Anatomy Link Frequency
CD86 2
Ccr7 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 19 99.36 Very High Very High Very High
chemokine 20 97.66 Very High Very High Very High
Inflammation 6 79.00 Quite High
Inflammatory mediators 1 29.72 Quite Low
anesthesia 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 7 79.00 Quite High
Eosinophilia 1 58.68 Quite High
Hypersensitivity 7 56.44 Quite High
Eczema 22 50.00 Quite Low
Asthma 3 43.00 Quite Low
Rhinitis 3 5.76 Low Low
Toxicity 6 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Heart Rate Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study we found that 24-hr DINP exposure significantly increased the production of the TH2-attracting chemokines TARC/CCL17 (Figure 3A) and MDC/CCL22 (Figure 3B) but not the TH1-polarizing cytokine IL-12p40 (data not shown), and increased the expression of CCR7, CXCR4 (Figure 3C,D), MHC class II, CD80, and CD86 (Figure 3E,F) in BMDCs.
Positive_regulation (increased) of Gene_expression (expression) of CCR7 in CD86 associated with chemokine and cytokine
1) Confidence 0.27 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.25 Pain Relevance 0.24

General Comments

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