INT305846

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.24
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4) nucleus (Polk)
DNA binding (Polk) nucleotidyltransferase activity (Polk)
Anatomy Link Frequency
T cells 6
Polk (Mus musculus)
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 60 83.52 Quite High
cytokine 57 76.80 Quite High
Inflammation 18 57.08 Quite High
Inflammatory mediators 3 7.80 Low Low
anesthesia 3 5.00 Very Low Very Low Very Low
halothane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 21 100.00 Very High Very High Very High
INFLAMMATION 21 57.08 Quite High
Eczema 66 50.00 Quite Low
Eosinophilia 3 36.76 Quite Low
Toxicity 18 33.52 Quite Low
Asthma 9 21.08 Low Low
Disease 12 5.00 Very Low Very Low Very Low
Body Weight 9 5.00 Very Low Very Low Very Low
Rhinitis 9 5.00 Very Low Very Low Very Low
Heart Rate Under Development 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a previous study Lee et al. (2004) showed that in vitro and/or in vivo exposure to DEHP and DINP enhances IL-4 production in CD4+ T cells and activation of IL-4 gene promoter containing binding sites for the NFAT (nuclear factor of activated T cells) transcription factor.
DINP Positive_regulation (enhances) of Gene_expression (production) of IL-4 in T cells
1) Confidence 0.13 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.08 Pain Relevance 0
DINP-exposed BMDCs consequently stimulated IL-4 production in the cocultures with Dp-sensitized T cells (Figure 4B).
DINP Positive_regulation (stimulated) of Gene_expression (production) of IL-4 in T cells
2) Confidence 0.11 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.06 Pain Relevance 0.15
That study and our present findings suggest that DEHP and DINP may enhance allergic responses by enhancing IL-4 production in CD4+ T cells via an NFAT-dependent pathway.
DINP Positive_regulation (enhancing) of Gene_expression (production) of IL-4 in T cells associated with hypersensitivity
3) Confidence 0.11 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.10 Pain Relevance 0

General Comments

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