INT305877

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.45
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Atp6v0a2) transport (Atp6v0a2) mitochondrion (Pcx)
plasma membrane (Atp6v0a2) cytoplasm (Atp6v0a2)
Anatomy Link Frequency
brain 2
Pcx (Mus musculus)
Atp6v0a2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 87.84 High High
agonist 2 34.08 Quite Low
Central nervous system 6 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Neurobehavioral 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 42 97.40 Very High Very High Very High
Metastasis 50 95.20 Very High Very High Very High
Melanoma 24 90.76 High High
Stress 6 85.32 High High
Brain Tumor 12 64.56 Quite High
Body Weight 4 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Central Nervous System Disease 4 5.00 Very Low Very Low Very Low
Parkinson's Disease 2 5.00 Very Low Very Low Very Low
Poisoning 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other redox-regulated candidate pathways that may be involved in PCB-induced alterations of TJ protein expression include MAP kinase (Krizbai et al. 2005) and PI3K (Schreibelt et al. 2007).
PCB Regulation (alterations) of Gene_expression (expression) of TJ
1) Confidence 0.01 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854723 Disease Relevance 0.56 Pain Relevance 0.04
Thus, the leaky BBB due to PCB-induced alterations of TJ expression in brain microvessels may facilitate transcapillary transfer of tumor cells and contribute to the development of brain metastasis.


PCB Regulation (alterations) of Gene_expression (expression) of TJ in brain associated with cancer and metastasis
2) Confidence 0.01 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854723 Disease Relevance 0.88 Pain Relevance 0

General Comments

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