INT305891

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.51
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (H19) cellular_component (H19)
Anatomy Link Frequency
embryos 2
H19 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 1 71.88 Quite High
pain pelvic 2 61.68 Quite High
Pain 1 56.44 Quite High
Hippocampus 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gestational Diabetes 12 98.88 Very High Very High Very High
Birth Weight 10 96.12 Very High Very High Very High
Uterine Fibroids 94 83.72 Quite High
Diabetes Mellitus 13 82.64 Quite High
Impaired Glucose Tolerance 1 71.88 Quite High
Obesity 4 70.76 Quite High
Hemorrhage 3 62.44 Quite High
Reprotox - General 3 2 61.68 Quite High
Pain 1 56.44 Quite High
Aging 1 49.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two studies in mice have reported that exposure of fetuses to induced maternal diabetes and of embryos before implantation to in vitro insulin affected expression of two imprinted neighboring genes, H19 and IGF2, by altering their methylation status and resulted in changes in fetal development and birth weight (Shao et al. 2007, 2008).
Regulation (affected) of Gene_expression (expression) of H19 in embryos associated with birth weight and gestational diabetes
1) Confidence 0.33 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854766 Disease Relevance 1.51 Pain Relevance 0.15

General Comments

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