INT3060

Context Info Confidence 0.59 First Reported 1977 Last Reported 2010 Negated 1 Speculated 4 Reported most in Abstract Documents 94 Total Number 98 Disease Relevance 46.75 Pain Relevance 18.51

extracellular space (Bche) extracellular region (Bche) endoplasmic reticulum (Bche)

Anatomy Link Frequency plasma 17 brain 4 liver 2 spinal 2 nerve 2 Bche (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 41 100.00 aspirin 7 100.00 agonist 181 99.90 algil 1 99.90 halothane 1 99.88 nMDA receptor 62 99.80 GABA receptor 1 99.64 Inflammation 85 99.48 intrathecal 14 99.44 Antinociceptive 12 99.36

Disease Link Frequency Relevance Heat Depression 72 100.00 Disease 2914 99.96 Eclampsia 4 99.82 Amnesia 21 99.72 Tremor 59 99.60 Respiratory Paralysis 4 99.60 INFLAMMATION 105 99.48 Toxicity 95 99.46 Stress 146 99.40 Diabetes Mellitus 34 99.38

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Enhanced mortality from succinylcholine is generally observed when serum butyrylcholinesterase is inhibited 55-94%.

Negative_regulation (inhibited) of butyrylcholinesterase

1) Confidence 0.59 Published 1999 Journal J. Biochem. Mol. Toxicol. Section Abstract Doc Link 9890196 Disease Relevance 0.38 Pain Relevance 0.05

The antinociceptive activity of donepezil, a novel cholinesterase inhibitor, was investigated in the mouse hot plate test.

Negative_regulation (inhibitor) of cholinesterase associated with antinociceptive

2) Confidence 0.59 Published 2002 Journal Headache Section Abstract Doc Link 12482211 Disease Relevance 0.13 Pain Relevance 0.53

Physostigmine, a central and peripheral cholinesterase inhibitor produced tremors, and at high doses death, by respiratory paralysis.

Negative_regulation (inhibitor) of cholinesterase in respiratory associated with tremor, respiratory paralysis and death

3) Confidence 0.58 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6286926 Disease Relevance 0.80 Pain Relevance 0.50

Neostigmine, a selective peripheral cholinesterase inhibitor, induced respiratory paralysis which was not affected by clonidine pretreatment.

Negative_regulation (inhibitor) of cholinesterase in respiratory associated with respiratory paralysis and clonidine

4) Confidence 0.58 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6286926 Disease Relevance 0.81 Pain Relevance 0.68

In general anesthesia with thiopentone and halothane, the pseudocholinesterase activity diminished.

Negative_regulation (diminished) of pseudocholinesterase associated with anesthesia and halothane

5) Confidence 0.58 Published 1977 Journal Acta Anaesthesiol Belg Section Abstract Doc Link 612115 Disease Relevance 0 Pain Relevance 0.42

Pseudocholinesterase deficiency: an additional preoperative consideration in outpatient diagnostic procedures.

Negative_regulation (deficiency) of Pseudocholinesterase associated with anesthesia

6) Confidence 0.58 Published 1977 Journal South. Med. J. Section Title Doc Link 877646 Disease Relevance 0 Pain Relevance 0.10

At therapeutic concentrations needed to treat cardiac arrhythmias (2 to 5 micrograms/ml), quinidine inhibited pseudocholinesterase activity by 60% to 70%.

Negative_regulation (inhibited) of pseudocholinesterase

7) Confidence 0.57 Published 1987 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 3674164 Disease Relevance 0 Pain Relevance 0.09

These results were corroborated with two other specific inhibitors of AChE and BChE, tolserine and bis-norcymserine, respectively.

Negative_regulation (inhibitors) of BChE

8) Confidence 0.57 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17212694 Disease Relevance 0.23 Pain Relevance 0.12

Physostigmine decreased atrial cholinesterase activity by 80% and increased the fraction of stimulation-evoked unhydrolyzed 14C-acetylcholine in the persufates from 58 to 86%.

Negative_regulation (decreased) of cholinesterase

9) Confidence 0.57 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7121614 Disease Relevance 0 Pain Relevance 0.41

The authors previously reported a case of decreased pseudocholinesterase activity in a patient with HELLP syndrome.

Negative_regulation (decreased) of pseudocholinesterase associated with syndrome

10) Confidence 0.56 Published 2007 Journal Reprod Sci Section Abstract Doc Link 17636231 Disease Relevance 0.47 Pain Relevance 0

The prevalence of reduced pseudocholinesterase activity lower than normal limit was 60.0% (9/15) in patients with HELLP syndrome, 33.3% (5/15) in patients with severe preeclampsia, and 6.6% (1/15) in women with normal pregnancy, respectively (P =.009).

Negative_regulation (reduced) of pseudocholinesterase associated with syndrome and pre-eclampsia

11) Confidence 0.56 Published 2007 Journal Reprod Sci Section Abstract Doc Link 17636231 Disease Relevance 0.77 Pain Relevance 0.06

It was assumed that the reduced pseudocholinesterase activity in HELLP syndrome is associated with impaired liver function.

Negative_regulation (reduced) of pseudocholinesterase in liver associated with syndrome

12) Confidence 0.56 Published 2007 Journal Reprod Sci Section Abstract Doc Link 17636231 Disease Relevance 0.61 Pain Relevance 0

Considering the increased prevalence of reduced pseudocholinesterase activity in patients with HELLP syndrome, the authors suggest that whenever general anesthesia is applied in these patients, the anesthesiologist should be aware that the patient may show slow metabolic degradation of choline-ester drugs.

Negative_regulation (reduced) of pseudocholinesterase associated with anesthesia and syndrome

13) Confidence 0.56 Published 2007 Journal Reprod Sci Section Abstract Doc Link 17636231 Disease Relevance 0.69 Pain Relevance 0.10

The influence of clonidine on the toxicity produced by two irreversible, organophosphate cholinesterase inhibitors, soman and echothiophate, was studied in mice.

Negative_regulation (inhibitors) of cholinesterase associated with toxicity and clonidine

14) Confidence 0.56 Published 1986 Journal Life Sci. Section Abstract Doc Link 3784771 Disease Relevance 0.65 Pain Relevance 0.38

Plasma cholinesterase activity was significantly reduced with the use of neostigmine but not with edrophonium (P < 0.001).

Neg (not) Negative_regulation (reduced) of Plasma cholinesterase in Plasma

15) Confidence 0.51 Published 1995 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 7484027 Disease Relevance 0 Pain Relevance 0.04

We report a case of decreased plasma pseudocholinesterase activity in a patient with hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome.

Negative_regulation (decreased) of pseudocholinesterase in platelets associated with syndrome and hemolysis

16) Confidence 0.51 Published 2004 Journal Am J Perinatol Section Abstract Doc Link 15311366 Disease Relevance 0.36 Pain Relevance 0.08

The findings suggest that prolactin may exert its cholinomimetic activity by inhibition of cholinesterase.

Negative_regulation (inhibition) of cholinesterase

17) Confidence 0.48 Published 1988 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2900321 Disease Relevance 0 Pain Relevance 0.40

Complaints (headache, dizziness, fatigue, nausea, breathing problems, abdominal cramps, and tingling in extremities) were associated with within-normal depressions in cholinesterase activity.

Negative_regulation (depressions) of cholinesterase associated with colic, depression, vomiting, dizziness, fatigue and headache

18) Confidence 0.46 Published 1992 Journal Isr. J. Med. Sci. Section Abstract Doc Link 1330977 Disease Relevance 0.76 Pain Relevance 0.15

Plasma cholinesterase activity was decreased to 29% of control at 15 min and remained at approximately 60% of the control after neostigmine administration.

Negative_regulation (decreased) of Plasma cholinesterase in Plasma

19) Confidence 0.45 Published 1995 Journal Anesth. Analg. Section Abstract Doc Link 7486038 Disease Relevance 0 Pain Relevance 0.21

Organophosphorus pesticide-induced butyrylcholinesterase inhibition and potentiation of succinylcholine toxicity in mice.

Negative_regulation (inhibition) of butyrylcholinesterase associated with aspirin and toxicity

20) Confidence 0.43 Published 1999 Journal J. Biochem. Mol. Toxicol. Section Title Doc Link 9890196 Disease Relevance 0.38 Pain Relevance 0.14

General Comments

This test has worked.