INT306006

Context Info Confidence 0.06 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.63 Pain Relevance 0.04

extracellular space (CD14, LBP) extracellular region (CD14, LBP) lipid binding (LBP) transport (LBP) plasma membrane (CD14)

CD14 (Homo sapiens) LBP (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 22 87.20 ketamine 12 5.00 Inflammation 12 5.00 Morphine 6 5.00 Inflammatory response 6 5.00 Central nervous system 5 5.00 Nicotine 4 5.00 Opioid 4 5.00 antagonist 3 5.00 agonist 3 5.00

Disease Link Frequency Relevance Heat Sepsis 39 93.00 Death 4 80.52 Fungal Infection 1 72.08 INFLAMMATION 19 5.00 Infection 5 5.00 Pain 3 5.00 Disease 3 5.00 Endotoxemia 3 5.00 Critical Illness 2 5.00 Cardiovascular Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

About 12 years ago, the discovery of the Toll-like receptor (TLR) unravelled the missing link between endotoxin recognition by LBP and CD14 and the intracellular signalling pathway, leading to the activation and translocation of NF?

CD14 Binding (recognition) of LBP

1) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.63 Pain Relevance 0.04

General Comments

This test has worked.