INT306008

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.41
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 30 97.84 Very High Very High Very High
chemokine 1 74.00 Quite High
Inflammatory response 16 67.00 Quite High
Inflammation 38 5.00 Very Low Very Low Very Low
ketamine 16 5.00 Very Low Very Low Very Low
Morphine 6 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Nicotine 4 5.00 Very Low Very Low Very Low
Opioid 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Burns 222 98.32 Very High Very High Very High
Urological Neuroanatomy 32 85.64 High High
Sepsis 47 84.40 Quite High
Critical Illness 2 84.36 Quite High
INFLAMMATION 55 66.64 Quite High
Injury 127 48.96 Quite Low
Endotoxemia 3 35.12 Quite Low
Infection 11 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reverse transcription-generated cDNA encoding TLR2, TLR4, and TNF?
Positive_regulation (generated) of Transcription (transcription) of TLR4
1) Confidence 0.50 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.14 Pain Relevance 0
Interestingly, LPS stimulation increased the sTLR4 mRNA expression, suggesting a negative feedback to inhibit excessive cytokine production.
Positive_regulation (increased) of Transcription (expression) of TLR4 associated with cytokine
2) Confidence 0.49 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.42 Pain Relevance 0.16
LPS supplement significantly increased TLR4 protein and mRNA expression of intestinal mucosa in thermal injured mice in comparison with commensal depletion + burn group.


Positive_regulation (increased) of Transcription (expression) of TLR4 protein associated with burns
3) Confidence 0.46 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.86 Pain Relevance 0

General Comments

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