INT306018

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.92
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, Tlr9) plasma membrane (Tlr4, Tlr9) intracellular (Tlr4, Tlr9)
cytoplasm (Tlr4, Tlr9) endosome (Tlr9) endoplasmic reticulum (Tlr9)
Tlr4 (Mus musculus)
Tlr9 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 2 79.92 Quite High
cytokine 22 74.52 Quite High
ketamine 12 72.48 Quite High
Inflammatory stimuli 2 68.28 Quite High
Inflammation 12 61.04 Quite High
Morphine 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Nicotine 4 5.00 Very Low Very Low Very Low
Opioid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Paralysis 1 92.96 High High
Sepsis 39 91.96 High High
Apoptosis 1 89.52 High High
INFLAMMATION 19 67.96 Quite High
Disease 3 61.64 Quite High
Systemic Lupus Erythematosus 1 61.24 Quite High
Malaria 1 60.32 Quite High
Sleep Disorders 1 57.92 Quite High
Peritonitis 1 40.80 Quite Low
Infection 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence, chloroquine may act at 2 different levels: down-regulation of TLR4 expression and interfering with the intracellular trafficking of LPS through its action on TLR9.
LPS Binding (action) of TLR9
1) Confidence 0.15 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.92 Pain Relevance 0.27

General Comments

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