INT306019

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.91
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tlr4, LY96) extracellular space (LY96) signal transduction (Tlr4)
extracellular region (LY96) intracellular (Tlr4) cytoplasm (Tlr4)
Anatomy Link Frequency
MD2 1
immune cells 1
internal 1
Tlr4 (Mus musculus)
LY96 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 9 98.44 Very High Very High Very High
cytokine 66 84.20 Quite High
Inflammation 36 74.96 Quite High
Inflammatory response 18 60.92 Quite High
chemokine 3 54.32 Quite High
headache 3 15.12 Low Low
Inflammatory mediators 3 5.76 Low Low
ketamine 36 5.00 Very Low Very Low Very Low
Morphine 18 5.00 Very Low Very Low Very Low
Central nervous system 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 3 95.84 Very High Very High Very High
Disease 9 94.68 High High
Sepsis 117 91.28 High High
Infection 15 80.44 Quite High
INFLAMMATION 57 74.96 Quite High
Endotoxemia 9 73.84 Quite High
Critical Illness 6 64.68 Quite High
Peritonitis 3 26.56 Quite Low
Fever 3 16.32 Low Low
Chills 3 15.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The crystal structure of the TLR4-MD2 complex with bound eritoran was recently described, suggesting that eritoran mechanism of action lies within its binding in a large hydrophobic internal pocket in MD2 [31].
TLR4-MD2 Binding (binding) of MD2 in internal
1) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.27 Pain Relevance 0.27
While the major signalling pathway of LPS lies within its binding to the MD2/TLR4 complex, several reports have indicated that endotoxin may enter immune cells [48] and localize in the Golgi apparatus and other vesicles [49].
LPS Binding (binding) of MD2 in immune cells
2) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.41 Pain Relevance 0.12
In the presence of soluble MD2, this protein binds LPS and inhibits LPS-induced TNF?
LPS Binding (binds) of MD2 in MD2
3) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.23 Pain Relevance 0.10

General Comments

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