INT306058

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.10
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ZGLP1)
Anatomy Link Frequency
ileum 2
plasma 1
ZGLP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 1 92.74 High High
Endocannabinoid 10 81.88 Quite High
agonist 15 76.96 Quite High
nud 2 69.04 Quite High
antagonist 2 68.76 Quite High
Dopamine 9 59.80 Quite High
Nucleus accumbens 4 57.84 Quite High
Neurotransmitter 5 54.40 Quite High
addiction 4 53.16 Quite High
Inflammation 320 50.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 5 99.80 Very High Very High Very High
Diabetes Mellitus 166 93.76 High High
Disorder Of Lipid Metabolism 4 89.88 High High
Metabolic Disorder 2 88.72 High High
Obesity 245 87.84 High High
Fatty Liver 1 86.92 High High
Disease 17 86.64 High High
Alcoholic Fatty Liver 1 86.32 High High
Appetite Loss 17 84.88 Quite High
Overweight 7 78.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endogenous GLP-1 and GIP have half-lives of <2 minutes and 5–7 minutes, respectively, before they are rapidly degraded by the ubiquitous enzyme, DPP-4.16 DPP-4 is widely expressed in multiple tissues, including the central nervous system, kidney, lung, adrenal gland, liver, intestine, spleen, testis, and pancreas, as well as on the surfaces of lymphocytes and macrophages.16,17 As a result of DPP-4 degradative activity, intact and biologically active GLP-1 represents only 10%–20% of total plasma GLP-1.20 By inhibiting the enzymatic activity of DPP-4, circulating plasma levels of active GIP and GLP-1 can be increased 2-fold to 3-fold.2,21–23
Positive_regulation (increased) of GLP-1 in plasma associated with central nervous system
1) Confidence 0.21 Published 2010 Journal Core Evidence Section Body Doc Link PMC2963920 Disease Relevance 0.15 Pain Relevance 0.08
Activation of GLP-1 receptor is accompanied with expansion of beta-cell mass due to stimulation of cell proliferation and promotion of antiapoptotic pathways coupled with beta-cell survival[22].
Positive_regulation (Activation) of GLP-1
2) Confidence 0.13 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2883206 Disease Relevance 1.01 Pain Relevance 0.03
As mentioned earlier, much of the success of gastric bypass surgery is related to the increase in satiety hormones (PYY and GLP-1) released from the ileum.
Positive_regulation (increase) of GLP-1 in ileum
3) Confidence 0.04 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2952901 Disease Relevance 0.12 Pain Relevance 0.11
Unlike other gastric bypass methods, this surgery also increases the release of gut hormones such as PYY and GLP-1 from the L-cells in the ileum, to give a profound degree of satiety [91].
Positive_regulation (increases) of GLP-1 in ileum
4) Confidence 0.02 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2952901 Disease Relevance 0.61 Pain Relevance 0.17
Intake of food depresses the hunger signals and leads to an increase in satiety signals such as CCK, GLP-1, PYY, insulin, and leptin.
Positive_regulation (increase) of GLP-1
5) Confidence 0.01 Published 2010 Journal Chemical Reviews Section Body Doc Link PMC2855180 Disease Relevance 0.21 Pain Relevance 0.11

General Comments

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