INT306124

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Context Info
Confidence 0.72
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 3.68
Pain Relevance 0

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signal transduction (FGF7) extracellular space (FGF7) extracellular region (FGF7)
Golgi apparatus (FGF7)
Anatomy Link Frequency
keratinocytes 2
FGF7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 16 5.00 Very Low Very Low Very Low
Pain 16 5.00 Very Low Very Low Very Low
tolerance 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 640 99.68 Very High Very High Very High
Lung Cancer 8 88.12 High High
Malignant Neoplastic Disease 24 81.60 Quite High
Leukemia 8 67.92 Quite High
Skin Cancer 24 41.84 Quite Low
Salivary Gland Disease 8 23.88 Low Low
Injury 8 11.88 Low Low
Head & Neck Cancer 24 8.60 Low Low
Mucositis 16 5.00 Very Low Very Low Very Low
INFLAMMATION 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Relative quantification of mRNA expression for KGF and KGF receptor was performed with SYBR Green PCR Master Mix (Eurogentec, Seraing, Belgium) using a thermal cycler ABI PRISM 7700 (Perkin-Elmer-Applied Biosynthesis, Foster City, CA).
Transcription (expression) of KGF receptor
1) Confidence 0.72 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.22 Pain Relevance 0
Real-time PCR was performed to test for radiation-induced changes in KGF and KGF receptor mRNA expression.
Transcription (expression) of KGF
2) Confidence 0.72 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.67 Pain Relevance 0
FigureĀ 2b shows that KGF recptor mRNA expression in primary keratinocytes is upregulated at both time points and radiation doses, while KGF receptor mRNA expression in HaCat cells is nearly unaffected by radiation.


Transcription (expression) of KGF receptor in keratinocytes
3) Confidence 0.72 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.13 Pain Relevance 0
Real-time PCR was performed to test for radiation-induced changes in KGF and KGF receptor mRNA expression.
Transcription (expression) of KGF receptor
4) Confidence 0.72 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.66 Pain Relevance 0
A plausible explanation for the lack of KGF-induced (recombinant KGF) stimulated proliferation in the present study as well as for lacking radioprotection in the former study (Hille et al. 2003) had been the very low level of KGF receptor mRNA expression in the tumour cell cultures.
Transcription (expression) of KGF receptor associated with cancer
5) Confidence 0.72 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.56 Pain Relevance 0
Relative quantification of mRNA expression for KGF and KGF receptor was performed with SYBR Green PCR Master Mix (Eurogentec, Seraing, Belgium) using a thermal cycler ABI PRISM 7700 (Perkin-Elmer-Applied Biosynthesis, Foster City, CA).
Transcription (expression) of KGF
6) Confidence 0.72 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.22 Pain Relevance 0
In accordance with the Western Blot results, significant KGF receptor mRNA expression was only found in primary keratinocytes and HaCat cells.
Transcription (expression) of KGF receptor in keratinocytes
7) Confidence 0.72 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.21 Pain Relevance 0
One plausible explanation for the lacking effect of KGF was the very low level of KGF receptor mRNA expression in the tumour cells.
Transcription (expression) of KGF receptor associated with cancer
8) Confidence 0.53 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 1.02 Pain Relevance 0

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