INT306254

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.29
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TLR2, LY96) extracellular space (LY96) signal transduction (TLR2)
extracellular region (LY96) intracellular (TLR2) cytoplasm (TLR2)
TLR2 (Homo sapiens)
LY96 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 106 96.64 Very High Very High Very High
cytokine 17 76.40 Quite High
chemokine 1 75.52 Quite High
Inflammation 19 66.16 Quite High
Osteoarthritis 2 51.16 Quite High
dexamethasone 7 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Etanercept 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 103 96.64 Very High Very High Very High
Autoimmune Disease 5 91.36 High High
Leukemia 5 90.12 High High
Lymphatic System Cancer 1 89.68 High High
Systemic Lupus Erythematosus 3 79.28 Quite High
Systemic Sclerosis 3 78.96 Quite High
INFLAMMATION 22 66.16 Quite High
Osteoarthritis 2 51.16 Quite High
Disease 12 45.12 Quite Low
Apoptosis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
So the interaction between LY96 in synovial tissue and TLR2 or TLR4 in the PBMC may indicate that the interaction between these two tissues in RA is mediated by the TLR signaling pathway.
TLR2 Binding (interaction) of LY96 associated with arthritis
1) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 1.29 Pain Relevance 0.36

General Comments

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