INT306255

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.07

nucleus (IRF6, TFAM) DNA binding (IRF6, TFAM) cytosol (IRF6) mitochondrion (TFAM) cytoplasm (IRF6)

IRF6 (Homo sapiens) TFAM (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 17 89.08 Arthritis 106 18.96 Etanercept 3 6.56 Infliximab 1 5.60 Inflammation 19 5.00 dexamethasone 7 5.00 methotrexate 6 5.00 metalloproteinase 4 5.00 Inflammatory response 3 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Cancer 11 49.92 Necrosis 2 49.44 Apoptosis 12 25.36 Rheumatoid Arthritis 103 18.96 Insulin Resistance 2 18.40 INFLAMMATION 22 5.00 Disease 12 5.00 Leukemia 5 5.00 Arthritis 5 5.00 Stress 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It has been shown that in cells expressing the 299D-399T TLR4, LPS activated the transcription factor NFB and increased the expression of IL6 and TNF-.

LPS Positive_regulation (activated) of transcription factor

1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0 Pain Relevance 0.07

General Comments

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