INT306267

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.83
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (INCENP, TP53) protein complex (INCENP, TP53) cytoplasm (INCENP, TP53)
cytosol (INCENP, TP53) cell differentiation (TP53) nucleoplasm (TP53)
INCENP (Homo sapiens)
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 6 100.00 Very High Very High Very High
Pain 2 88.40 High High
Arthritis 106 87.76 High High
dexamethasone 7 29.08 Quite Low
Inflammation 19 5.00 Very Low Very Low Very Low
cytokine 17 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Etanercept 3 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 5 97.84 Very High Very High Very High
Cancer 11 96.88 Very High Very High Very High
Pain 2 88.40 High High
Rheumatoid Arthritis 103 87.76 High High
Aging 1 80.92 Quite High
Apoptosis 12 80.44 Quite High
Stress 5 77.80 Quite High
INFLAMMATION 22 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Leukemia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro studies have shown that methotrexate caused single- and double-strand DNA breaks is associated with TP53 [72]–[74].
In vitro Binding (associated) of TP53 associated with methotrexate
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.83 Pain Relevance 0.27

General Comments

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