INT306272

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.54
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CRKL, JUN) nucleoplasm (JUN) nuclear chromosome (JUN)
aging (JUN) nucleus (JUN) DNA binding (JUN)
Anatomy Link Frequency
SH2 1
SH3 1
CRKL (Homo sapiens)
JUN (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 212 90.92 High High
Inflammation 38 44.40 Quite Low
cytokine 34 5.00 Very Low Very Low Very Low
dexamethasone 14 5.00 Very Low Very Low Very Low
methotrexate 12 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Etanercept 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Osteoarthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 206 90.92 High High
Disease 24 72.24 Quite High
Leukemia 10 55.04 Quite High
INFLAMMATION 44 44.40 Quite Low
Apoptosis 24 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Stress 10 5.00 Very Low Very Low Very Low
Autoimmune Disease 10 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRKL, containing SH2 and SH3 domains, had been shown to activate the RAS and JUN kinase signaling pathways.
CRKL Positive_regulation (activate) of JUN in SH3
1) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.27 Pain Relevance 0.07
CRKL, containing SH2 and SH3 domains, had been shown to activate the RAS and JUN kinase signaling pathways.
CRKL Positive_regulation (activate) of JUN in SH2
2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.27 Pain Relevance 0.07

General Comments

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