INT306276

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.73
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (NFIB) nucleus (NFIB) intracellular (NFIB)
DNA binding (NFIB)
Anatomy Link Frequency
synovium 1
NFIB (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 212 98.36 Very High Very High Very High
Osteoarthritis 4 97.76 Very High Very High Very High
Inflammation 38 97.24 Very High Very High Very High
cytokine 34 96.72 Very High Very High Very High
dexamethasone 14 5.00 Very Low Very Low Very Low
methotrexate 12 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Etanercept 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 206 98.36 Very High Very High Very High
Osteoarthritis 4 97.76 Very High Very High Very High
INFLAMMATION 44 97.24 Very High Very High Very High
Autoimmune Disease 10 88.80 High High
Disease 24 81.28 Quite High
Apoptosis 24 67.68 Quite High
Cancer 22 43.56 Quite Low
Arthritis 10 41.04 Quite Low
Leukemia 10 5.00 Very Low Very Low Very Low
Stress 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apart from the increased concentration of the active NF-B in synovium, its binding to DNA was found to be much stronger in RA compared to osteoarthritis patients [104].
NF-B Binding (binding) of in synovium associated with osteoarthritis and arthritis
1) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.94 Pain Relevance 0.42
For example, Decoy oligodeoxynucleotides (ODNs), short double stranded DNAs containing a consensus sequence for the NF-B binding sites, specifically block NF-B binding to the target genes and are effective in the down-regulation of pro-inflammatory cytokine gene expression in vitro [105].
NF-B Binding (binding) of associated with inflammation and cytokine
2) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.79 Pain Relevance 0.36

General Comments

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