INT306283

Context Info Confidence 0.36 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.42 Pain Relevance 0.14

cytosol (CRKL) signal transducer activity (CRKL)

Anatomy Link Frequency SH2 1 SH3 1 CRKL (Homo sapiens)

Pain Link Frequency Relevance Heat Arthritis 212 90.92 Inflammation 38 39.28 cytokine 34 5.00 dexamethasone 14 5.00 methotrexate 12 5.00 metalloproteinase 8 5.00 Inflammatory response 6 5.00 Etanercept 6 5.00 Pain 4 5.00 Osteoarthritis 4 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 206 90.92 Disease 24 67.12 Leukemia 10 49.92 INFLAMMATION 44 39.28 Apoptosis 24 5.00 Cancer 22 5.00 Arthritis 10 5.00 Stress 10 5.00 Autoimmune Disease 10 5.00 Death 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CRKL, containing SH2 and SH3 domains, had been shown to activate the RAS and JUN kinase signaling pathways.

Gene_expression (containing) of CRKL in SH3

1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.21 Pain Relevance 0.07

CRKL, containing SH2 and SH3 domains, had been shown to activate the RAS and JUN kinase signaling pathways.

Gene_expression (containing) of CRKL in SH2

2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.21 Pain Relevance 0.07

General Comments

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