INT306295

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.43
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (NFIB) nucleus (NFIB) intracellular (NFIB)
DNA binding (NFIB)
NFIB (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 51 99.18 Very High Very High Very High
Inflammation 57 98.98 Very High Very High Very High
Arthritis 318 97.76 Very High Very High Very High
Osteoarthritis 6 74.00 Quite High
dexamethasone 21 5.00 Very Low Very Low Very Low
methotrexate 18 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
Etanercept 9 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 15 99.88 Very High Very High Very High
INFLAMMATION 66 98.98 Very High Very High Very High
Rheumatoid Arthritis 309 97.76 Very High Very High Very High
Disease 36 97.36 Very High Very High Very High
Apoptosis 36 89.76 High High
Osteoarthritis 6 74.00 Quite High
Cancer 33 65.64 Quite High
Arthritis 15 63.12 Quite High
Systemic Sclerosis 9 8.32 Low Low
Systemic Lupus Erythematosus 9 6.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glucocorticoiks are an example of commonly used therapeutics that can modulate the NF-B pathway through several mechanisms mentioned in [106].
Regulation (modulate) of NF-B
1) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.70 Pain Relevance 0.28
Apart from the specific NF-B-directed therapies, a variety of drugs used in the conventional treatment of autoimmune diseases have effects on NF-B activity.
Regulation (effects) of NF-B associated with autoimmune disease
2) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.75 Pain Relevance 0.28
Patients with RA present constitutively high serum levels of pre-inflammatory cytokines, including TNF-, IL1 and IL6, which are NF-B target genes, suggesting activation of this pathway in the course of RA disease.
Regulation (target) of NF-B associated with inflammation, disease, cytokine and arthritis
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.98 Pain Relevance 0.41

General Comments

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