INT306306

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Context Info
Confidence 0.78
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.98
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl5)
Anatomy Link Frequency
lung 1
respiratory 1
Cxcl5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 108 94.52 High High
chemokine 20 92.12 High High
Inflammatory response 28 77.52 Quite High
cytokine 44 56.48 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pneumonia 92 94.72 High High
INFLAMMATION 52 77.68 Quite High
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Bacterial Infection 4 5.00 Very Low Very Low Very Low
Hemorrhage 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At high doses, neither S-LPS nor R-LPS required CD14 to induce PMN influx or TNF and LIX secretion in BALF, which is in line with the results of others obtained with LPS stimulated macrophages [21] or a mouse model of LPS-induced lung inflammation [18].
Localization (secretion) of LIX in lung associated with inflammation and pneumonia
1) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.15 Pain Relevance 0.15
This possibility is supported by the lack of an effect of (s)CD14 on LIX release after high dose LPS administration, considering that respiratory epithelial cells are important for both PMN influx and LIX secretion [20], [24].
Localization (release) of LIX in respiratory
2) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.27 Pain Relevance 0.13
At this LPS dose, neither sCD14 administration nor CD14 deficiency influenced LIX release.
Localization (release) of LIX
3) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.15 Pain Relevance 0.07
The local release of LIX was facilitated by the presence of CD14 at lower S-LPS and R-LPS doses, i.e.
Localization (release) of LIX
4) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.41 Pain Relevance 0.20

General Comments

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