INT306323

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.55
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, Ticam1) plasma membrane (Tlr4) intracellular (Tlr4)
signal transducer activity (Ticam1) cytoplasm (Tlr4)
Tlr4 (Mus musculus)
Ticam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 62 91.52 High High
cytokine 44 55.52 Quite High
Inflammatory response 16 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 36 91.52 High High
Pneumonia 46 77.96 Quite High
Myocardial Infarction 27 61.28 Quite High
Shock 2 43.28 Quite Low
Coronary Artery Disease 4 18.96 Low Low
Reperfusion Injury 4 17.28 Low Low
Injury 11 5.00 Very Low Very Low Very Low
Targeted Disruption 11 5.00 Very Low Very Low Very Low
Hypertrophy 10 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, it was established that CD14 is required for activation of the TLR4/TRIF pathway by either S-LPS or R-LPS [14].
LPS Positive_regulation (activation) of TRIF
1) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.25 Pain Relevance 0.12
Recently, it was established that CD14 is required for activation of the TLR4/TRIF pathway by either S-LPS or R-LPS [14].
LPS Positive_regulation (activation) of TRIF
2) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.25 Pain Relevance 0.12
TLR4 can activate TRIF-dependent pathways without MyD88 association, leading to activation of the transcription factor IRF3, in turn producing interferon and costimulatory molecules.


TLR4 Positive_regulation (activate) of TRIF
3) Confidence 0.09 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.06 Pain Relevance 0.05

General Comments

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