INT30638

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Context Info
Confidence 0.69
First Reported 1983
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 17
Total Number 20
Disease Relevance 4.63
Pain Relevance 8.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
hypothalamus 3
brain 3
plasma 2
anterior 2
MDCK 2
Dbi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 24 100.00 Very High Very High Very High
antagonist 9 99.98 Very High Very High Very High
Central grey 21 99.52 Very High Very High Very High
Morphine 2 99.46 Very High Very High Very High
withdrawal 10 98.84 Very High Very High Very High
addiction 8 98.84 Very High Very High Very High
Spinal cord 2 98.56 Very High Very High Very High
Analgesic 6 98.50 Very High Very High Very High
Neurotransmitter 5 98.20 Very High Very High Very High
alcohol 8 96.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 35 99.52 Very High Very High Very High
Injury 26 99.52 Very High Very High Very High
Opiate Addiction 4 96.40 Very High Very High Very High
Infection 60 95.76 Very High Very High Very High
Arthritis 3 94.04 High High
Pain 11 87.92 High High
Anxiety Disorder 1 83.28 Quite High
Body Weight 3 82.56 Quite High
Leishmaniasis 3 82.12 Quite High
Stress 5 81.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Withdrawal for 3 days caused significant physical signs and further increased the DBI mRNA expression.
Positive_regulation (increased) of Gene_expression (expression) of DBI mRNA associated with withdrawal
1) Confidence 0.69 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15950760 Disease Relevance 0.17 Pain Relevance 0.90
We found that chronic morphine treatment enabled CPP and increased the DBI mRNA expression in crucial brain regions of addiction.
Positive_regulation (increased) of Gene_expression (expression) of DBI mRNA in brain associated with addiction and morphine
2) Confidence 0.69 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15950760 Disease Relevance 0.19 Pain Relevance 0.83
Antisense p21 ODN transfection of MDCK cells at 400 and 600 nM showed increased cell proliferation as compared to cells transfected with scrambled control ODN (Fig. 5b).
Positive_regulation (Antisense) of Gene_expression (transfection) of ODN in MDCK
3) Confidence 0.49 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.27 Pain Relevance 0
In another experiment, the brain content of beta-EP expressed as nanograms per region, increased from 12.6 +/- 0.29 to 14.7 +/- 0.33 in the hypothalamus, from 4.09 +/- 0.44 to 6.03 +/- 0.34 in the midbrain, and from 0.93 +/- 0.11 to 1.32 +/- 0.06 ng in the amygdala at 16-17 days of gestation compared with that in nonpregnant controls (P less than 0.01).
Positive_regulation (increased) of in hypothalamus Gene_expression (expressed) of beta-EP in brain associated with midbrain and amygdala
4) Confidence 0.48 Published 1983 Journal Endocrinology Section Abstract Doc Link 6313328 Disease Relevance 0 Pain Relevance 0.22
Compared with control and sham-operation groups, both SP immuno-reaction (IR) and beta-EP IR positive cells in the hypothalamus in model group increased significantly in the number (P < 0.01), suggesting an upregulation of SP and beta-EP expression after occurrence of gastralgia.
Positive_regulation (upregulation) of Gene_expression (expression) of beta-EP in hypothalamus
5) Confidence 0.40 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 19916289 Disease Relevance 0 Pain Relevance 0
beta-endorphin (beta-EP) levels increase in maternal plasma starting from the 10th to the 12th week of pregnancy and reach a peak during labor and at delivery.
Positive_regulation (increase) of Gene_expression (levels) of beta-EP in plasma
6) Confidence 0.38 Published 1994 Journal J Psychosom Obstet Gynaecol Section Abstract Doc Link 7881506 Disease Relevance 0.08 Pain Relevance 0.08
CONCLUSION: Both low-frequency and high-frequency EA of "Zusanli (ST 36)" can effectively relieve gastric distension-induced gastralgia in the rat, and the effect of high-frequency EA is better, which may be closely related to its actions in promoting the release and synthesis of hypothalamic beta-EP and SP.


Positive_regulation (promoting) of Gene_expression (synthesis) of beta-EP
7) Confidence 0.27 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 19916289 Disease Relevance 0 Pain Relevance 0
A beta-endorphin (beta EP) injection in the third ventricle stimulated PRL secretion and induced furthermore a PRL secretory reaction to TRH injected intravenously 20 min later.
Positive_regulation (stimulated) of Gene_expression (injection) of EP in third ventricle
8) Confidence 0.21 Published 1987 Journal Life Sci. Section Abstract Doc Link 3104708 Disease Relevance 0 Pain Relevance 0.35
Although the increase in extracellular beta-EP produced by the other stressors was relatively rapid, there was a 90-min delay before alcohol administration caused beta-EP levels to exceed that of saline-injected controls.
Positive_regulation (increase) of Gene_expression (produced) of beta-EP associated with alcohol
9) Confidence 0.19 Published 2004 Journal Neuroscience Section Abstract Doc Link 15283974 Disease Relevance 0.24 Pain Relevance 0.48
These data indicate obvious analgesic effects of the cells after the transplantation and the possible exogenous upregulation of transfected beta-EP gene expression in vivo.
Spec (possible) Positive_regulation (upregulation) of Gene_expression (expression) of beta-EP associated with analgesic
10) Confidence 0.14 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 11031086 Disease Relevance 0.19 Pain Relevance 0.70
In contrast, testosterone or its metabolites may exert negative autocrine modulation of beta EP production.
Spec (may) Positive_regulation (exert) of Gene_expression (production) of EP
11) Confidence 0.12 Published 1988 Journal Endocrinology Section Abstract Doc Link 2962854 Disease Relevance 0 Pain Relevance 0.19
The level of ir-beta-endorphin (beta-EP) was elevated both in the plasma and the anterior, but not the neurointermediate, pituitary.
Neg (not) Positive_regulation (elevated) of Gene_expression (level) of beta-EP in anterior
12) Confidence 0.12 Published 1986 Journal J. Neurosci. Section Abstract Doc Link 2871141 Disease Relevance 0.56 Pain Relevance 0.61
Mice were treated with CpG ODN fma1555 or CpG ODN 1555 (50 ?
Positive_regulation (with) of Gene_expression (treated) of CpG ODN
13) Confidence 0.10 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1156963 Disease Relevance 0.53 Pain Relevance 0
RP-HPLC analysis of purified CpG ODN fma1555 was performed using an analytical 5 ?
Positive_regulation (performed) of Gene_expression (analysis) of CpG ODN
14) Confidence 0.10 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1156963 Disease Relevance 0 Pain Relevance 0
RP-HPLC analysis of purified CpG ODN fma1555 was performed using an analytical 5 ?
Positive_regulation (purified) of Gene_expression (analysis) of CpG ODN
15) Confidence 0.10 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1156963 Disease Relevance 0 Pain Relevance 0
EP improves cardiac function after I/R injury
Positive_regulation (improves) of Gene_expression (improves) of EP associated with injury
16) Confidence 0.09 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2995973 Disease Relevance 0.50 Pain Relevance 0.11
These data indicate obvious analgesic effects of the cells after the transplantation and the possible exogenous upregulation of transfected beta-EP gene expression in vivo.
Spec (possible) Positive_regulation (transfected) of Gene_expression (expression) of beta-EP associated with analgesic
17) Confidence 0.09 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 11031086 Disease Relevance 0.19 Pain Relevance 0.69
RT-PCR data displayed that AVP enhanced proenkephalin and proopiomelanocortin (Pro-beta-Ep) rather than prodynorphin mRNA expressions in culture PAG tissues, and V(2) receptor antagonist weakened proenkephalin and proopiomelanocortin (Pro-beta-Ep), not prodynorphin mRNA expressions in culture PAG tissues, but V(1) receptor antagonist did not influence these mRNA expressions in culture PAG tissues.
Neg (not) Positive_regulation (weakened) of Gene_expression (expressions) of Pro-beta-Ep associated with antagonist and central grey
18) Confidence 0.06 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17113946 Disease Relevance 0.82 Pain Relevance 1.48
The results showed that AVP elevated the concentrations of leucine-enkephalin (L-Ek), methionine-enkephalin (M-Ek) and beta-endorphin (beta-Ep), but did not change the concentrations of dynorphinA(1-13) (DynA(1-13)), OXT, classical neurotransmitters including achetylcholine (Ach), choline (Ch), serotonin (5-HT), gamma-aminobutyric acid (GABA), glutamate (Glu), dopamine (DA), norepinephrine (NE) and epinephrine (E), and their metabolic products in PAG perfusion liquid.
Positive_regulation (elevated) of Gene_expression (concentrations) of beta-Ep associated with dopamine, glutamate, gaba, neurotransmitter, enkephalin, central grey and serotonin
19) Confidence 0.03 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17341433 Disease Relevance 0.82 Pain Relevance 1.64
mM, while the peptide and ODN concentrations were raised to 1?
Positive_regulation (raised) of Gene_expression (peptide) of ODN
20) Confidence 0.03 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647317 Disease Relevance 0 Pain Relevance 0

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