INT306468

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.30
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MBL2) extracellular region (MBL2)
MBL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 60 93.08 High High
cytokine 21 87.68 High High
nud 58 45.20 Quite Low
metalloproteinase 2 40.40 Quite Low
antagonist 1 40.32 Quite Low
palliative 2 31.92 Quite Low
Antihistamine 4 21.36 Low Low
cINOD 1 21.12 Low Low
peptic ulcer disease 1 14.44 Low Low
chemokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 78 99.92 Very High Very High Very High
Pancreatic Cancer 98 99.84 Very High Very High Very High
Acute-phase Reaction 2 98.12 Very High Very High Very High
Infection 68 96.96 Very High Very High Very High
INFLAMMATION 57 93.08 High High
Skin Infection 36 91.68 High High
Staphylococcus Infection 12 90.32 High High
Dermatological Disease 36 89.52 High High
Disease 86 84.88 Quite High
Syndrome 24 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There are three functional single nucleotide polymorphisms within exon 1 of the MBL2 gene which lead to low serum MBL levels.
Positive_regulation (lead) of Gene_expression (levels) of MBL2
1) Confidence 0.47 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.21 Pain Relevance 0
Genotype analysis revealed specific point mutations in the MBL2 promoter in all 6 patients and a variant MASP-2 gene in one patient.
Positive_regulation (mutations) of Gene_expression (promoter) of MBL2
2) Confidence 0.47 Published 2010 Journal Clin Mol Allergy Section Abstract Doc Link PMC2856528 Disease Relevance 1.27 Pain Relevance 0.08
There are three functional single nucleotide polymorphisms within exon 1 of the MBL2 gene which lead to low serum MBL levels.
Positive_regulation (lead) of Gene_expression (levels) of MBL
3) Confidence 0.41 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.21 Pain Relevance 0
MBL-null mice incubated with intravenous S. aureus had a blunted production of TNF-?
Positive_regulation (blunted) of Gene_expression (production) of MBL
4) Confidence 0.41 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.49 Pain Relevance 0.09
Further validation studies in an independent set of serum samples from 16 pancreatic cancer patients and 16 non-cancer-bearing controls demonstrated increased levels of MBL2 and MLCK2.
Positive_regulation (increased) of Gene_expression (levels) of MBL2 associated with cancer and pancreatic cancer
5) Confidence 0.37 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2906412 Disease Relevance 0.92 Pain Relevance 0
MBL2, which was found in this study to be increased in pancreatic cancer serum, has not been identified previously as a marker of pancreatic cancer.
Positive_regulation (increased) of Gene_expression (found) of MBL2 associated with pancreatic cancer
6) Confidence 0.35 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2906412 Disease Relevance 0.78 Pain Relevance 0
Genotyping for TLR2 and MBL genes
Positive_regulation (for) of Gene_expression (genes) of MBL
7) Confidence 0.20 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2966931 Disease Relevance 0.42 Pain Relevance 0

General Comments

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