INT306468

Context Info Confidence 0.47 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 4.30 Pain Relevance 0.17

extracellular space (MBL2) extracellular region (MBL2)

MBL2 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 60 93.08 cytokine 21 87.68 nud 58 45.20 metalloproteinase 2 40.40 antagonist 1 40.32 palliative 2 31.92 Antihistamine 4 21.36 cINOD 1 21.12 peptic ulcer disease 1 14.44 chemokine 6 5.00

Disease Link Frequency Relevance Heat Cancer 78 99.92 Pancreatic Cancer 98 99.84 Acute-phase Reaction 2 98.12 Infection 68 96.96 INFLAMMATION 57 93.08 Skin Infection 36 91.68 Staphylococcus Infection 12 90.32 Dermatological Disease 36 89.52 Disease 86 84.88 Syndrome 24 81.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

There are three functional single nucleotide polymorphisms within exon 1 of the MBL2 gene which lead to low serum MBL levels.

Positive_regulation (lead) of Gene_expression (levels) of MBL2

1) Confidence 0.47 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.21 Pain Relevance 0

Genotype analysis revealed specific point mutations in the MBL2 promoter in all 6 patients and a variant MASP-2 gene in one patient.

Positive_regulation (mutations) of Gene_expression (promoter) of MBL2

2) Confidence 0.47 Published 2010 Journal Clin Mol Allergy Section Abstract Doc Link PMC2856528 Disease Relevance 1.27 Pain Relevance 0.08

There are three functional single nucleotide polymorphisms within exon 1 of the MBL2 gene which lead to low serum MBL levels.

Positive_regulation (lead) of Gene_expression (levels) of MBL

3) Confidence 0.41 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.21 Pain Relevance 0

MBL-null mice incubated with intravenous S. aureus had a blunted production of TNF-?

Positive_regulation (blunted) of Gene_expression (production) of MBL

4) Confidence 0.41 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.49 Pain Relevance 0.09

Further validation studies in an independent set of serum samples from 16 pancreatic cancer patients and 16 non-cancer-bearing controls demonstrated increased levels of MBL2 and MLCK2.

Positive_regulation (increased) of Gene_expression (levels) of MBL2 associated with cancer and pancreatic cancer

5) Confidence 0.37 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2906412 Disease Relevance 0.92 Pain Relevance 0

MBL2, which was found in this study to be increased in pancreatic cancer serum, has not been identified previously as a marker of pancreatic cancer.

Positive_regulation (increased) of Gene_expression (found) of MBL2 associated with pancreatic cancer

6) Confidence 0.35 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2906412 Disease Relevance 0.78 Pain Relevance 0

Genotyping for TLR2 and MBL genes

Positive_regulation (for) of Gene_expression (genes) of MBL

7) Confidence 0.20 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2966931 Disease Relevance 0.42 Pain Relevance 0

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