INT306493

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.39
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tpt1) extracellular space (Tpt1) transcription factor binding (Tpt1)
cytoplasm (Tpt1)
Anatomy Link Frequency
MCF-7 2
Tpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 9 99.56 Very High Very High Very High
Apoptosis 22 71.88 Quite High
Cancer 29 38.16 Quite Low
Breast Cancer 12 5.00 Very Low Very Low Very Low
Reprotox - General 1 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Metastasis 2 5.00 Very Low Very Low Very Low
Embolism 2 5.00 Very Low Very Low Very Low
Carcinoma 2 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast in MCF-7 CLU cells, over-expression of secretory clusterin appears to block the effects of TNFalpha on both cell cycle (by blocking the increase in p21) and cell death by preventing the proteolytic activation of Bax (Figure 3 panel B).
Negative_regulation (blocking) of Positive_regulation (increase) of p21 in MCF-7 associated with death
1) Confidence 0.17 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.39 Pain Relevance 0

General Comments

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