INT306502

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.40
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnf, Tpt1) nucleoplasm (Tpt1) intracellular (Tnf)
extracellular matrix organization (Tnf) cytoplasm (Tpt1) cell proliferation (Tnf)
Anatomy Link Frequency
MCF-7 2
Tnf (Mus musculus)
Tpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 9 92.16 High High
Apoptosis 22 86.92 High High
Cancer 29 8.88 Low Low
Breast Cancer 12 5.00 Very Low Very Low Very Low
Reprotox - General 1 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Metastasis 2 5.00 Very Low Very Low Very Low
Embolism 2 5.00 Very Low Very Low Very Low
Carcinoma 2 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In untransfected MCF-7 cells, TNFalpha induces the expression of p21 (Figure 3 panel A) and stimulates the proteolytic activation of Bax, an upstream regulatory protein that initiates mitochondrial membrane permeability transition and is surrogate marker for cell death.
TNFalpha Positive_regulation (induces) of Gene_expression (expression) of p21 in MCF-7 associated with death
1) Confidence 0.17 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.40 Pain Relevance 0

General Comments

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