INT306520

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Msh3) nucleus (Msh3) enzyme binding (Msh3)
DNA binding (Msh3)
Msh3 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 21 99.84 Very High Very High Very High
Analgesic 38 99.76 Very High Very High Very High
Pain threshold 3 86.48 High High
Neuropeptide 8 84.56 Quite High
antinociception 27 79.76 Quite High
Dynorphin 20 76.44 Quite High
Pain 8 69.80 Quite High
Antinociceptive 21 51.68 Quite High
Potency 3 43.52 Quite Low
agonist 2 35.12 Quite Low
Disease Link Frequency Relevance Heat
Pain 15 86.48 High High
Nociception 5 65.52 Quite High
Disease 58 37.68 Quite Low
Targeted Disruption 13 37.16 Quite Low
Syndrome 4 5.00 Very Low Very Low Very Low
Spinocerebellar Ataxia Type 2 4 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression levels of Msh3, Ogg1 and Cbp did not correlate with instability index and Msh2 expression level showed a weak negative correlation with instability index (Figure 6A, Additional file 2).
Negative_regulation (levels) of Msh3
1) Confidence 0.40 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0 Pain Relevance 0
However, both analgesic effects of EM-1 were reversed by NLX, which may predict the possible inhibitory effects of Bestatin, although no direct research has been done up to now.


Negative_regulation (reversed) of EM-1 associated with analgesic and narcan
2) Confidence 0.01 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.22 Pain Relevance 0.76

General Comments

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