INT306658

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.20
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Map1lc3b) intracellular (Map1lc3b) cytoplasm (Map1lc3b)
Anatomy Link Frequency
vesicles 1
Map1lc3b (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
carbamazepine 2 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Substantia nigra 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 8 70.40 Quite High
Apoptosis 9 69.92 Quite High
Neurodegenerative Disease 27 63.44 Quite High
Disease 35 48.24 Quite Low
Parkinson's Disease 12 45.60 Quite Low
Tauopathy 5 45.24 Quite Low
Toxicity 15 34.96 Quite Low
Autosomal Disorder 1 28.88 Quite Low
Communicable Diseases 2 26.96 Quite Low
Cancer 5 26.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The only known mammalian protein that specifically associates with the autophagosome membrane (as opposed to other vesicles) is MAP1 LC3 (microtubule-associated protein 1 light chain 3), which is post-translationally modified into cytosolic LC3-I, which conjugates with phosphatidylethanolamine upon autophagy induction to form autophagosome-associated LC3-II (13).
microtubule-associated protein 1 light chain 3 Binding (associates) of in vesicles
1) Confidence 0.13 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2856980 Disease Relevance 0.13 Pain Relevance 0
The second ubiquitination-like reaction involves the conjugation of microtubule-associated protein 1 light chain 3 (MAP1-LC3/LC3/Atg8) to the lipid phosphatidylethanolamine (PE).
microtubule-associated protein 1 light chain 3 Binding (conjugation) of
2) Confidence 0.04 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.07 Pain Relevance 0

General Comments

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