INT306663

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.28
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Atg5)
Anatomy Link Frequency
brains 1
Atg5 (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 100.00 Very High Very High Very High
Neurodegenerative Disease 11 98.36 Very High Very High Very High
Parkinson's Disease 3 78.88 Quite High
Frontotemporal Dementia 2 47.36 Quite Low
Creutzfeldt Jakob Disease 1 34.88 Quite Low
Disease 20 29.68 Quite Low
Tauopathy 4 26.68 Quite Low
Toxicity 6 16.40 Low Low
Autosomal Disorder 1 10.32 Low Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies have shown that constitutive autophagy may play a pivotal role in the clearance of normally occurring cellular misfolded proteins, as loss of basal autophagy by conditional knock-out of key autophagy genes, such as Atg5 and Atg7, in mouse brains resulted in a neurodegenerative phenotype and the formation of protein aggregates (14, 15).
Negative_regulation (loss) of Atg5 in brains associated with targeted disruption and neurodegenerative disease
1) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2856980 Disease Relevance 0.28 Pain Relevance 0

General Comments

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