INT306713

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.39
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleolus (Pgr) nucleus (Pgr)
enzyme binding (Pgr) cytoplasm (Pgr)
Anatomy Link Frequency
heart 2
Pgr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anticonvulsant 17 98.12 Very High Very High Very High
carbamazepine 18 90.68 High High
Gabapentin 2 28.00 Quite Low
Lamotrigine 4 23.00 Low Low
sodium channel 15 10.32 Low Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Action potential 2 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
antiepileptic Drug 1 5.00 Very Low Very Low Very Low
Antiepileptic agent 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypothermia 1 99.20 Very High Very High Very High
Death 1 95.32 Very High Very High Very High
Heart Rate Under Development 2 89.76 High High
Hyponatremia 2 56.64 Quite High
Convulsion 43 52.92 Quite High
Epilepsy 17 50.00 Quite Low
Anaemia 1 37.84 Quite Low
Partial Seizures 8 5.00 Very Low Very Low Very Low
Vomiting 5 5.00 Very Low Very Low Very Low
Obesity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electrocardiogram changes, specifically a mild prolongation of the PR interval, have been observed in patients taking eslicarbazepine.29 In recommending approval of eslicarbazepine in Europe, the European Medicines Agency advised a contraindication to the administration of eslicarbazepine to patients with 2nd or 3rd degree heart block and caution with co-administration of any drugs known to increase the PR interval.29
Regulation (changes) of Positive_regulation (prolongation) of PR in heart associated with heart rate under development
1) Confidence 0.06 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857610 Disease Relevance 0.39 Pain Relevance 0.24

General Comments

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