INT306723

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.44
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il22) extracellular region (Il22)
Anatomy Link Frequency
keratinocytes 1
Il22 (Mus musculus)
Pain Link Frequency Relevance Heat
psoriasis 55 99.58 Very High Very High Very High
Inflammatory response 12 98.20 Very High Very High Very High
Inflammation 85 96.96 Very High Very High Very High
cytokine 71 90.96 High High
chemokine 8 90.56 High High
antagonist 4 82.20 Quite High
Etanercept 17 31.68 Quite Low
Arthritis 14 5.00 Very Low Very Low Very Low
Multiple sclerosis 12 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 68 99.58 Very High Very High Very High
Asthma 104 99.32 Very High Very High Very High
INFLAMMATION 97 97.84 Very High Very High Very High
Skin Diseases 3 97.36 Very High Very High Very High
Endotoxemia 1 90.12 High High
Urinary Tract Infection 2 78.96 Quite High
Bacterial Respiratory Disease 2 71.96 Quite High
Eczema 1 71.92 Quite High
Bacterial Infection 2 70.28 Quite High
Infection 37 68.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the contribution neither of IL-22 nor of IL-26 to asthma pathogenesis has been understood so far.
IL-22 Neg (neither) Binding (contribution) of associated with asthma
1) Confidence 0.11 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.67 Pain Relevance 0.03
Further, it was demonstrated that psoriasis mediators IL-17 and IL-22 synergistically induce the production of IL-20 subfamily proteins in cultured human keratinocytes and the expression of the IL-22 receptor (IL-22R) was also increased in epidermal lesions versus normal skin.23 IL-17 and IL-22 coordinately enhanced cytokine, chemokine, and growth factor production depending on the amount of IL-22R expression.
IL-22 Binding (induce) of in keratinocytes associated with chemokine, psoriasis and cytokine
2) Confidence 0.09 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.06 Pain Relevance 0.45
The receptor IL-10RB for IL-10 (which binds also IL-22) serves as an accessory chain essential for the active IL-10 receptor complex and to initiate IL-10 induced signal transduction events.
IL-22 Binding (binds) of
3) Confidence 0.01 Published 2010 Journal Immun Ageing Section Body Doc Link PMC2933667 Disease Relevance 0.71 Pain Relevance 0.49

General Comments

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