INT306726

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 5.52
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il22) extracellular region (Il22)
Anatomy Link Frequency
macrophages 1
endothelial cells 1
Th1 cells 1
epithelial cells 1
fibroblasts 1
Il22 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 182 100.00 Very High Very High Very High
psoriasis 61 97.40 Very High Very High Very High
rheumatoid arthritis 196 97.12 Very High Very High Very High
Crohn's disease 196 87.72 High High
Arthritis 29 84.64 Quite High
Inflammation 140 83.92 Quite High
chemokine 12 83.64 Quite High
methotrexate 24 5.00 Very Low Very Low Very Low
Etanercept 17 5.00 Very Low Very Low Very Low
Multiple sclerosis 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 74 97.40 Very High Very High Very High
Rheumatoid Arthritis 196 97.12 Very High Very High Very High
Infection 25 96.62 Very High Very High Very High
Inflammatory Bowel Disease 219 94.76 High High
Disease 279 93.84 High High
Arthritis 15 84.64 Quite High
INFLAMMATION 134 83.92 Quite High
Autoimmune Disease 8 73.72 Quite High
Sprains And Strains 4 68.52 Quite High
Acanthosis 1 65.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The invasion of extracellular bacteria into the intestinal mucosa triggers the expression of IL-23A, driving Th17 cells to release IL-17A, IL-17F, IL-21, IL-22 and IL-26, which in turn exert a number of proinflammatory effects on intestinal epithelial cells, endothelial cells, macrophages and fibroblasts [10].
Localization (release) of IL-22 in fibroblasts
1) Confidence 0.57 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.61 Pain Relevance 0.25
This CD4 T cell subset may be similar to that recently reported to secrete IL-22 but not IL-17 and to be involved in the skin pathophysiology of psoriasis [43,44].
Neg (not) Localization (secrete) of IL-22 in skin associated with psoriasis
2) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.86 Pain Relevance 0.50
IL-22 has been characterised as one of the effector cytokines secreted by Th17 cells [9,30,31], but it is also produced by Th1 cells [38].
Localization (secreted) of IL-22 in Th1 cells associated with cytokine
3) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.99 Pain Relevance 0.70
The invasion of extracellular bacteria into the intestinal mucosa triggers the expression of IL-23A, driving Th17 cells to release IL-17A, IL-17F, IL-21, IL-22 and IL-26, which in turn exert a number of proinflammatory effects on intestinal epithelial cells, endothelial cells, macrophages and fibroblasts [10].
Localization (release) of IL-22 in macrophages
4) Confidence 0.19 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.61 Pain Relevance 0.25
The invasion of extracellular bacteria into the intestinal mucosa triggers the expression of IL-23A, driving Th17 cells to release IL-17A, IL-17F, IL-21, IL-22 and IL-26, which in turn exert a number of proinflammatory effects on intestinal epithelial cells, endothelial cells, macrophages and fibroblasts [10].
Localization (release) of IL-22 in endothelial cells
5) Confidence 0.19 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.61 Pain Relevance 0.25
The invasion of extracellular bacteria into the intestinal mucosa triggers the expression of IL-23A, driving Th17 cells to release IL-17A, IL-17F, IL-21, IL-22 and IL-26, which in turn exert a number of proinflammatory effects on intestinal epithelial cells, endothelial cells, macrophages and fibroblasts [10].
Localization (release) of IL-22 in epithelial cells
6) Confidence 0.19 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.61 Pain Relevance 0.25
IL-22 is also increased in psoriatic lesions and in plasma and these levels correlate with disease severity.18 Multiple reports have also implicated the IL-23 dependent IL-22, but not IL-17 production, in protective immunity to infection with gram-negative organisms such as Salmonella enteritidis in the respiratory and digestive epithelium.19–21 Recently, a Th22 cell subpopulation (characterized by the secretion of IL-22 and TNF-?)
Localization (secretion) of IL-22 in respiratory associated with psoriasis, disease and infection
7) Confidence 0.19 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.23 Pain Relevance 0.36

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox