INT306727

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.26
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il22) extracellular region (Il22)
Anatomy Link Frequency
respiratory 2
Il22 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 36 92.40 High High
psoriasis 55 85.16 High High
cytokine 20 70.08 Quite High
chemokine 2 28.80 Quite Low
Etanercept 17 5.00 Very Low Very Low Very Low
Arthritis 13 5.00 Very Low Very Low Very Low
Multiple sclerosis 11 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
Infliximab 5 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 31 99.20 Very High Very High Very High
Psoriasis 68 97.96 Very High Very High Very High
Infection 25 97.84 Very High Very High Very High
INFLAMMATION 36 92.40 High High
Autoimmune Disease 4 84.44 Quite High
Acanthosis 1 76.68 Quite High
Parakeratosis 1 58.68 Quite High
Hyperplasia 1 57.28 Quite High
Skin Diseases 3 37.52 Quite Low
Demyelinating Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-22 is also increased in psoriatic lesions and in plasma and these levels correlate with disease severity.18 Multiple reports have also implicated the IL-23 dependent IL-22, but not IL-17 production, in protective immunity to infection with gram-negative organisms such as Salmonella enteritidis in the respiratory and digestive epithelium.19–21 Recently, a Th22 cell subpopulation (characterized by the secretion of IL-22 and TNF-?)
Neg (not) Positive_regulation (implicated) of Neg (not) Positive_regulation (dependent) of IL-22 in respiratory associated with psoriasis, disease and infection
1) Confidence 0.12 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.26 Pain Relevance 0.30

General Comments

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