INT306730

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.04
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il22) extracellular region (Il22)
Anatomy Link Frequency
Th17 cells 2
Il22 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 36 100.00 Very High Very High Very High
cytokine 20 100.00 Very High Very High Very High
psoriasis 55 97.06 Very High Very High Very High
methotrexate 6 61.04 Quite High
corticosteroid 3 58.20 Quite High
cINOD 1 57.12 Quite High
Arthritis 13 54.68 Quite High
Pain 3 47.04 Quite Low
depression 1 26.28 Quite Low
Etanercept 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 36 100.00 Very High Very High Very High
Cancer 8 99.40 Very High Very High Very High
Necrosis 1 99.16 Very High Very High Very High
Psoriasis 68 97.06 Very High Very High Very High
Disease 31 58.56 Quite High
Seronegative Spondarthritis 13 54.68 Quite High
Pain 2 47.04 Quite Low
Increased Venous Pressure Under Development 2 46.64 Quite Low
Pressure And Volume Under Development 2 46.32 Quite Low
Arthralgia 3 32.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a newly developed, targeted biological agent, ustekinumab has demonstrated superior efficacy and safety in the treatment of plaque psoriasis by its unique mechanism of inhibiting IL-12/23 inflammatory pathways.7 IL-23 stimulates survival and proliferation of Th17 cells, a key cell that regulates the production of other inflammatory cytokines (IL-17, IL-22, IL-21, IL-6, tumor necrosis factor (TNF)-?)
Regulation (regulates) of Gene_expression (production) of IL-22 in Th17 cells associated with psoriasis, necrosis, inflammation, cancer and cytokine
1) Confidence 0.06 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.04 Pain Relevance 0.62

General Comments

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