INT306731

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.07
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il22, Il2) extracellular region (Il22, Il2)
Anatomy Link Frequency
keratinocytes 2
Il22 (Mus musculus)
Il2 (Mus musculus)
Pain Link Frequency Relevance Heat
psoriasis 55 99.58 Very High Very High Very High
Inflammation 36 96.80 Very High Very High Very High
cytokine 20 91.88 High High
chemokine 2 91.48 High High
antagonist 1 44.24 Quite Low
Etanercept 17 33.52 Quite Low
Arthritis 13 5.00 Very Low Very Low Very Low
Multiple sclerosis 11 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
Infliximab 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 68 99.58 Very High Very High Very High
Skin Diseases 3 97.36 Very High Very High Very High
INFLAMMATION 36 96.80 Very High Very High Very High
Infection 25 68.12 Quite High
Disease 31 62.56 Quite High
Autoimmune Disease 4 48.60 Quite Low
Acanthosis 1 40.84 Quite Low
Parakeratosis 1 22.84 Low Low
Hyperplasia 1 21.44 Low Low
Demyelinating Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, it was demonstrated that psoriasis mediators IL-17 and IL-22 synergistically induce the production of IL-20 subfamily proteins in cultured human keratinocytes and the expression of the IL-22 receptor (IL-22R) was also increased in epidermal lesions versus normal skin.23 IL-17 and IL-22 coordinately enhanced cytokine, chemokine, and growth factor production depending on the amount of IL-22R expression.
IL-22 Positive_regulation (induce) of Gene_expression (production) of IL-2 in keratinocytes associated with chemokine, psoriasis and cytokine
1) Confidence 0.12 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.07 Pain Relevance 0.46

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox