INT306735

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.25
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL23A)
Anatomy Link Frequency
skin 2
T cells 2
respiratory 2
IL23A (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 165 96.96 Very High Very High Very High
Inflammation 111 96.12 Very High Very High Very High
chemokine 12 89.20 High High
cytokine 68 88.64 High High
headache 15 84.64 Quite High
Arthritis 40 62.80 Quite High
Etanercept 51 57.56 Quite High
antagonist 3 52.20 Quite High
Multiple sclerosis 33 5.00 Very Low Very Low Very Low
methotrexate 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 204 99.50 Very High Very High Very High
Disease 102 99.20 Very High Very High Very High
Infection 76 97.60 Very High Very High Very High
INFLAMMATION 112 96.12 Very High Very High Very High
Common Cold 12 88.80 High High
Nasopharyngitis 9 86.00 High High
Headache 15 84.64 Quite High
Autoimmune Disease 13 84.44 Quite High
Arthralgia 9 83.52 Quite High
Acanthosis 3 76.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-22 is also increased in psoriatic lesions and in plasma and these levels correlate with disease severity.18 Multiple reports have also implicated the IL-23 dependent IL-22, but not IL-17 production, in protective immunity to infection with gram-negative organisms such as Salmonella enteritidis in the respiratory and digestive epithelium.19–21 Recently, a Th22 cell subpopulation (characterized by the secretion of IL-22 and TNF-?)
Neg (not) Positive_regulation (implicated) of Neg (not) Positive_regulation (dependent) of IL-23 in respiratory associated with psoriasis, disease and infection
1) Confidence 0.26 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.26 Pain Relevance 0.30
This kind of analysis is considered a conservative method, so the outstanding long-term efficacy rates yielded by those studies could possibly be underestimation of the real potential of this IL-12 and IL-23 inhibitor.42
Positive_regulation (underestimation) of Positive_regulation (potential) of IL-23
2) Confidence 0.26 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.55 Pain Relevance 0.15
In humans, IL-23 is clearly elevated in psoriatic lesions as indicated by increased levels of both p19 and p40 (subunits of IL-23) mRNA in lesional skin as compared to non-lesional skin, but the mRNA levels of p35 (subunit of IL-12) are not.30 These data suggest that IL-23 appears to play a more dominant role than IL-12 in psoriasis.
Positive_regulation (increased) of Positive_regulation (increased) of p19 in skin associated with psoriasis
3) Confidence 0.26 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.96 Pain Relevance 0.38
This phenotype is characterized by high capacity to present antigens and high capacity to produce IL-12 (promoting Th1 responses) and IL-23 (promoting maturation and survival of IL-17 producing T cells), as well as microbicidal nitric oxide and reactive oxygen intermediates.
Positive_regulation (promoting) of Positive_regulation (promoting) of IL-23 in T cells
4) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.48 Pain Relevance 0.21

General Comments

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