INT306736

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL18) extracellular space (IL18) extracellular region (IL18)
cell-cell signaling (IL18) cytoplasm (IL18)
IL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 55 77.52 Quite High
alcohol 2 44.44 Quite Low
cytokine 43 42.52 Quite Low
Inflammation 44 42.12 Quite Low
Etanercept 17 5.00 Very Low Very Low Very Low
Arthritis 13 5.00 Very Low Very Low Very Low
Multiple sclerosis 11 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
Infliximab 5 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 68 98.80 Very High Very High Very High
INFLAMMATION 44 42.12 Quite Low
Disease 31 5.00 Very Low Very Low Very Low
Infection 25 5.00 Very Low Very Low Very Low
Demyelinating Disease 16 5.00 Very Low Very Low Very Low
Seronegative Spondarthritis 13 5.00 Very Low Very Low Very Low
Cancer 11 5.00 Very Low Very Low Very Low
Skin Cancer 5 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 5 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We retrospectively selected endometrial samples with a high IL-18 mRNA expression (over 6.17) and low (below 4.1) or high TWEAK (over 6.86) mRNA expression to compare their NKp46 and TGF-?
Negative_regulation (samples) of Transcription (expression) of IL-18
1) Confidence 0.38 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0
Of the 17 subjects who received the IL-12/23 monoclonal antibody, 13 (76%) achieved PASI 75, compared with no placebo subjects. mRNA expression of IL-12, IL-23, IL-8, IL-18, and IFN-?
Negative_regulation (achieved) of Neg (no) Transcription (expression) of IL-18
2) Confidence 0.05 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.31 Pain Relevance 0.11

General Comments

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