INT306739

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.20
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL22) extracellular region (IL22) cell-cell signaling (IL22)
Anatomy Link Frequency
skin 2
keratinocytes 2
IL22 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 55 99.44 Very High Very High Very High
chemokine 9 98.04 Very High Very High Very High
psoriasis 61 97.48 Very High Very High Very High
cytokine 31 95.52 Very High Very High Very High
rheumatoid arthritis 11 87.24 High High
Etanercept 23 87.00 High High
Inflammation 50 83.68 Quite High
antagonist 3 72.24 Quite High
Multiple sclerosis 11 5.00 Very Low Very Low Very Low
Infliximab 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 53 99.44 Very High Very High Very High
Psoriasis 78 97.48 Very High Very High Very High
Rheumatoid Arthritis 13 87.24 High High
INFLAMMATION 47 83.68 Quite High
Skin Diseases 3 82.40 Quite High
Experimental Arthritis 1 64.24 Quite High
Disease 51 60.40 Quite High
Infection 25 53.16 Quite High
Cancer 12 50.00 Quite Low
Necrosis 5 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated IL-22 expression in the SF of PsA patients, a novel finding in our patients, suggests that the Th17 system may have an underlying role in both skin [20] and joint involvement.
Positive_regulation (Elevated) of Gene_expression (expression) of IL-22 in skin associated with arthritis
1) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945042 Disease Relevance 1.31 Pain Relevance 0.82
The data concluded that increased IL-22R expression in epidermal keratinocytes contributes to the pathogenesis of psoriasis through enhancing the coordinated effects of IL-22 and IL-17.
Positive_regulation (increased) of Gene_expression (expression) of IL-22R in keratinocytes associated with psoriasis
2) Confidence 0.01 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.89 Pain Relevance 0.54

General Comments

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