INT306745

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.25
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Il12a, IL23A) extracellular space (Il12a) cytoplasm (Il12a)
Anatomy Link Frequency
T-cells 1
Il12a (Mus musculus)
IL23A (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 275 98.96 Very High Very High Very High
methotrexate 30 85.64 High High
corticosteroid 15 82.80 Quite High
cytokine 100 82.00 Quite High
cINOD 5 81.72 Quite High
Inflammation 180 80.92 Quite High
Arthritis 65 79.28 Quite High
Pain 15 71.64 Quite High
depression 5 50.88 Quite High
Etanercept 85 8.24 Low Low
Disease Link Frequency Relevance Heat
Psoriasis 340 98.96 Very High Very High Very High
Disease 155 83.16 Quite High
INFLAMMATION 180 80.92 Quite High
Seronegative Spondarthritis 65 79.28 Quite High
Pain 10 71.64 Quite High
Increased Venous Pressure Under Development 10 71.24 Quite High
Pressure And Volume Under Development 10 70.92 Quite High
Arthralgia 15 56.92 Quite High
Arthropathy 5 55.80 Quite High
Anxiety Disorder 10 51.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ustekinumab does not associate with p35 subunit of IL-12 or the p19 subunit of IL-23, thus future medications may utilize these distinctions.
IL-12 Neg (not) Binding (associate) of p19
1) Confidence 0.10 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.50 Pain Relevance 0.22
Ustekinumab does not associate with p35 subunit of IL-12 or the p19 subunit of IL-23, thus future medications may utilize these distinctions.
p35 subunit Neg (not) Binding (associate) of IL-23
2) Confidence 0.10 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.50 Pain Relevance 0.22
Ustekinumab does not associate with p35 subunit of IL-12 or the p19 subunit of IL-23, thus future medications may utilize these distinctions.
IL-12 Neg (not) Binding (associate) of IL-23
3) Confidence 0.10 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.50 Pain Relevance 0.22
Ustekinumab does not associate with p35 subunit of IL-12 or the p19 subunit of IL-23, thus future medications may utilize these distinctions.
p35 subunit Neg (not) Binding (associate) of p19
4) Confidence 0.10 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.50 Pain Relevance 0.22
Both IL-12 and IL-23 have been associated with the pathogenesis of psoriasis, in part due to their relationship to the differentiation of naïve T-cells into Th1 and Th17 cells5,6 (Figure 1).
IL-12 Binding (associated) of IL-23 in T-cells associated with psoriasis
5) Confidence 0.09 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.24 Pain Relevance 0.69

General Comments

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