INT306747

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.51
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL23A, Il17a) extracellular space (Il17a)
IL23A (Homo sapiens)
Il17a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 20 98.84 Very High Very High Very High
Inflammatory response 1 96.92 Very High Very High Very High
psoriasis 55 5.00 Very Low Very Low Very Low
Inflammation 36 5.00 Very Low Very Low Very Low
Etanercept 17 5.00 Very Low Very Low Very Low
Arthritis 13 5.00 Very Low Very Low Very Low
Multiple sclerosis 11 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
Infliximab 5 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 36 96.92 Very High Very High Very High
Autoimmune Disease 4 94.12 High High
Salmonella Infection 2 86.40 High High
Infection 25 72.12 Quite High
Targeted Disruption 2 54.92 Quite High
Disease 31 51.12 Quite High
Latent Tuberculosis 2 33.92 Quite Low
Bacterial Infection 1 27.88 Quite Low
Mycobacterial Infection 3 19.92 Low Low
Candida Infection 2 19.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-independent activity; 2) that IL-12 and -23 have autocrine function on antigen-presenting cells (APCs) which may have an additive effect on cytokine production and thus microbicidal mechanisms; and 3) that IL-17, the production of with is stimulated by IL-23, but inhibited by IL-12 dependent immune mechanisms and is known to mediate inflammatory responses and play a role in the pathogenesis of various autoimmune disorders, function may be impaired.
IL-23 Positive_regulation (stimulated) of IL-17 associated with inflammatory response, autoimmune disease and cytokine
1) Confidence 0.05 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.51 Pain Relevance 0.16

General Comments

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