INT306786

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.71
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (STAR) transport (STAR) mitochondrion (STAR)
small molecule metabolic process (STAR)
STAR (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 8 95.12 Very High Very High Very High
Arthritis 2 78.44 Quite High
Bile 14 70.80 Quite High
cytokine 10 70.16 Quite High
Inflammation 130 69.76 Quite High
monoamine 2 66.72 Quite High
sSRI 10 65.20 Quite High
depression 12 56.40 Quite High
tolerance 8 53.12 Quite High
antidepressant 19 50.00 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 23 94.28 High High
Coronary Artery Disease 13 88.48 High High
Hyperlipidemia 4 85.24 High High
Dyslipidemia /

Combined Dyslipidemia

9 83.92 Quite High
Arthritis 2 78.44 Quite High
INFLAMMATION 135 69.76 Quite High
Disease 37 64.40 Quite High
Autoimmune Disease 2 62.48 Quite High
Depression 39 56.40 Quite High
Inflammatory Bowel Disease 94 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PCTPs bind their substrates via the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain, which can be found in 15 different human proteins that are involved in the control of lipid metabolism.
StAR Binding (bind) of
1) Confidence 0.47 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.45 Pain Relevance 0.23
Most showed no association to measures of efficacy, while one showed modest association for a particular haplotype in only a subset of the STAR*D sample [70].
STAR Neg (no) Binding (association) of
2) Confidence 0.22 Published 2010 Journal Curr Psychiatry Rep Section Body Doc Link PMC2965366 Disease Relevance 0.06 Pain Relevance 0.39
PCTPs bind their substrates via the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain, which can be found in 15 different human proteins that are involved in the control of lipid metabolism.
steroidogenic acute regulatory protein Binding (bind) of
3) Confidence 0.11 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.45 Pain Relevance 0.23
Among lipid-altering therapies, lowering LDL-C cholesterol with statins remains the most commonly used strategy in clinical practice.4–6 It has been shown to decrease the incidence of major cardiovascular events by 25% to 35%.
cholesterol Binding (lowering) of
4) Confidence 0.02 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857616 Disease Relevance 0.67 Pain Relevance 0

General Comments

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