INT306793

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (APOB) small molecule metabolic process (APOB) endoplasmic reticulum (APOB)
enzyme binding (APOB) lipid metabolic process (APOB) extracellular space (APOB)
APOB (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Paresthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 23 99.56 Very High Very High Very High
Increased Venous Pressure Under Development 53 83.32 Quite High
Dyslipidemia /

Combined Dyslipidemia

5 50.00 Quite Low
Coronary Artery Disease 13 5.00 Very Low Very Low Very Low
Hepatotoxicity 4 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Hyperlipidemia 4 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Pruritus 2 5.00 Very Low Very Low Very Low
Dysesthesia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In an early phase III pivotal trial, LERN (40 mg of laropiprant/2000 mg of niacin) significantly improved lipid parameters compared to placebo, and resulted in 18.4% reduction in LDL-C, 20% increase in HDL-C, 25.8% reduction in TG, 19.8% decrease in non-HDL-C cholesterol, 18.8% decrease in ApoB and 6.9% increase in ApoA-1.41 In this study, two-thirds of patients were on a statin at enrollment and were randomized to LERN, ERN or placebo.
Negative_regulation (decrease) of Positive_regulation (increase) of ApoB associated with disorder of lipid metabolism
1) Confidence 0.27 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857616 Disease Relevance 0.33 Pain Relevance 0

General Comments

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