INT30683

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Context Info
Confidence 0.36
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.96
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TRH) extracellular region (TRH) plasma membrane (TRH)
nucleus (TRH) cell-cell signaling (TRH) cytoplasm (TRH)
TRH (Homo sapiens)
Pain Link Frequency Relevance Heat
anticonvulsant 6 99.68 Very High Very High Very High
Opioid 9 99.38 Very High Very High Very High
Cholecystokinin 3 98.66 Very High Very High Very High
transdermal 18 92.40 High High
Somatostatin 3 90.80 High High
Enkephalin 3 85.76 High High
agonist 1 84.64 Quite High
narcan 1 76.24 Quite High
Neuropeptide 2 75.00 Quite High
opioid receptor 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Infantile Spasms 1 91.92 High High
Partial Seizures 1 89.28 High High
Convulsion 5 81.20 Quite High
Epilepsy 5 78.60 Quite High
Depression 3 71.92 Quite High
Toxicity 2 5.00 Very Low Very Low Very Low
Cadaver 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cholecystokinin (CCK) and its analogs, the opioid peptides beta-endorphin and FK33824, TRH analogs, and several dipeptides exhibit potent anticonvulsant properties in chemical, electroshock, and genetic model screens.
TRH Binding (exhibit) of associated with anticonvulsant, opioid and cholecystokinin
1) Confidence 0.36 Published 1986 Journal Adv Neurol Section Abstract Doc Link 2871723 Disease Relevance 0.83 Pain Relevance 0.93
Influence of heterologous stimuli in birds refractory to human pancreatic growth hormone-releasing (hpGRF) or thyrotrophin releasing hormone (TRH).
TRH Binding (refractory) of
2) Confidence 0.35 Published 1985 Journal Gen. Comp. Endocrinol. Section Title Doc Link 3926600 Disease Relevance 0 Pain Relevance 0
This suggested that the initial binding and saturation of the epidermal membrane by TRH was not affected by these materials (18).
TRH Binding (binding) of
3) Confidence 0.29 Published 2008 Journal AAPS J Section Body Doc Link PMC2751457 Disease Relevance 0.13 Pain Relevance 0.11
Specificity for the kappa-type of OPR was found based on the inability of mu- or delta-opioid peptides, as well as LHRH and TRH, to compete for [3H]EKC binding.
TRH Binding (binding) of associated with opioid
4) Confidence 0.28 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2892853 Disease Relevance 0 Pain Relevance 0.51

General Comments

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