INT306835

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.52
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (E2F2) nucleus (E2F2) DNA binding (E2F2)
transcription factor binding (E2F2)
E2F2 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 650 98.88 Very High Very High Very High
Inflammation 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 315 99.50 Very High Very High Very High
Lung Cancer 50 95.84 Very High Very High Very High
Cancer 210 87.68 High High
Apoptosis 30 73.72 Quite High
Body Weight 10 40.44 Quite Low
Reprotox - General 1 20 5.00 Very Low Very Low Very Low
Disease 15 5.00 Very Low Very Low Very Low
Metastasis 10 5.00 Very Low Very Low Very Low
Weight Loss 10 5.00 Very Low Very Low Very Low
Breast Cancer 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, our data suggest that capsaicin displays potent anti-proliferative activity in human SCLC cells by differentially regulating the E2F family of transcription factors.
Regulation (regulating) of E2F associated with qutenza and small cell lung cancer
1) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.51 Pain Relevance 0.77
Effect of E2F-siRNAs on the Anti-proliferative Activity of Capsaicin
Regulation (Effect) of E2F associated with qutenza
2) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.72 Pain Relevance 0.77
Previous studies have shown that a majority of human SCLCs have mutations in Rb and p53, as well as a dysregulation in the E2F-Rb pathway [3], [4], [5].
Regulation (dysregulation) of E2F
3) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.39 Pain Relevance 0.31
Therefore, we hypothesized that capsaicin displays anti-proliferative activity in human SCLCs by regulating the activity of the E2F family of transcription factors.
Regulation (regulating) of E2F associated with qutenza
4) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.68 Pain Relevance 0.59
Therefore, it is probable that the other two pocket proteins, p107 and p130, play a vital role in E2F regulation and cell proliferation in human SCLCs.
Regulation (regulation) of E2F
5) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.21 Pain Relevance 0.18

General Comments

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