INT306839

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.24
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (E2F1) nucleoplasm (E2F1) mitochondrion (E2F1)
nucleus (E2F1) DNA binding (E2F1) transcription factor binding (E2F1)
Anatomy Link Frequency
H69 2
E2F1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 130 96.04 Very High Very High Very High
Inflammation 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Gabapentin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 63 80.24 Quite High
Metastasis 5 80.04 Quite High
Cancer 57 79.16 Quite High
Apoptosis 7 32.64 Quite Low
Lung Cancer 10 5.00 Very Low Very Low Very Low
Reprotox - General 1 4 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Weight Loss 2 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low
Non-small-cell Lung Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In consistence with up-regulation of TSP-1 activity by over-expression of E2F-1, the knockdown of endogenous E2F-1 inhibited TSP-1 promoter activity significantly, implying that E2F-1 mediated regulation of TSP-1 is relevant in vivo.
Negative_regulation (inhibited) of Gene_expression (expression) of E2F-1
1) Confidence 0.39 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955548 Disease Relevance 0.16 Pain Relevance 0
Western blotting analysis showed that the transfection of the above mentioned siRNAs suppressed E2F1–6 protein levels in both H69 and DMS114 cells (Fig. 4, B and C, respectively).
Negative_regulation (suppressed) of Gene_expression (levels) of E2F1 in H69
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.08 Pain Relevance 0.61

General Comments

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