INT306844

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.81
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCNE2) nucleoplasm (CCNE2) nucleus (CCNE2)
cell division (CCNE2)
Anatomy Link Frequency
mammary glands 2
H69 1
CCNE2 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 390 99.54 Very High Very High Very High
Inflammation 13 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 189 99.12 Very High Very High Very High
Disease 41 98.46 Very High Very High Very High
Breast Cancer 252 95.42 Very High Very High Very High
Glioma 55 89.72 High High
Apoptosis 46 88.96 High High
Hyperplasia 4 81.04 Quite High
Cancer 378 78.60 Quite High
Aging 10 76.60 Quite High
Lung Cancer 32 75.40 Quite High
Colon Cancer 4 59.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, MMTV-cyclin D2 mice show increased proliferation of mammary glands in pregnant females, but alveolar differentiation is partially or completely inhibited.157 In one report, cyclin D3 was overexpressed in breast cancers, but there are limited data on its relationship to the phenotype of breast cancer and prognosis of patients.158 Keyomarsi et al showed that the absence of cyclin D1 or cyclin D3 protein expression was associated with improved disease-specific and overall survival, but the correlations were less striking than those for cyclin E.159

Cyclin E

Localization (those) of cyclin E in mammary glands associated with breast cancer and disease
1) Confidence 0.21 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.54 Pain Relevance 0
Indeed, MMTV-cyclin D2 mice show increased proliferation of mammary glands in pregnant females, but alveolar differentiation is partially or completely inhibited.157 In one report, cyclin D3 was overexpressed in breast cancers, but there are limited data on its relationship to the phenotype of breast cancer and prognosis of patients.158 Keyomarsi et al showed that the absence of cyclin D1 or cyclin D3 protein expression was associated with improved disease-specific and overall survival, but the correlations were less striking than those for cyclin E.159

Cyclin E

Localization (those) of Cyclin E in mammary glands associated with breast cancer and disease
2) Confidence 0.21 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.54 Pain Relevance 0
Our studies revealed that the treatment of human SCLC cells with capsaicin leads to differential recruitment of E2Fs on E2F-responsive promoters like cyclin E, TS, cdc25A and cdc6.
Localization (recruitment) of cyclin E associated with qutenza and small cell lung cancer
3) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.64 Pain Relevance 0.26
The treatment of H69 human SCLC cells with capsaicin leads to a switch in E2F subtypes on cyclin E, TS, cdc25A and cdc6 promoters; E2F1–3 are dissociated from the promoter, and E2F4 and p130 are recruited.
Localization (recruited) of cyclin E in H69 associated with qutenza and small cell lung cancer
4) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.73 Pain Relevance 0.41
We selected cyclin E, TS, cdc25A and cdc6.
Localization (selected) of cyclin E
5) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.14 Pain Relevance 0.85
In the present study, we show that the co-depletion of cathepsin B and uPAR arrests cells in the G1 phase primarily through the upregulation of p27Kip1 and that this pathway involves the downregulation of p-PI3K, p-AKT, D-type cyclin expression, and cyclin E/Cdk2 complex formation as well as the subsequent upregulation of the FOXO3a protein and its nuclear localization.
Localization (localization) of cyclin E
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.61 Pain Relevance 0
In the present study, we show that the co-depletion of cathepsin B and uPAR arrests cells in the G1 phase primarily through the upregulation of p27Kip1 and that this pathway involves the downregulation of p-PI3K, p-AKT, D-type cyclin expression, and cyclin E/Cdk2 complex formation as well as the subsequent upregulation of the FOXO3a protein and its nuclear localization.
Localization (localization) of cyclin E
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.61 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox