INT306853

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.37
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (E2F4) nucleus (E2F4) DNA binding (E2F4)
transcription factor binding (E2F4)
E2F4 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 390 99.32 Very High Very High Very High
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 189 92.56 High High
Cancer 126 67.56 Quite High
Lung Cancer 30 62.96 Quite High
Metastasis 6 37.80 Quite Low
Non-small-cell Lung Cancer 6 32.88 Quite Low
Genomic Instability 3 32.52 Quite Low
Apoptosis 18 5.00 Very Low Very Low Very Low
Reprotox - General 1 12 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Weight Loss 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, the recruitment of repressor E2F4 was enhanced by capsaicin treatment.
E2F4 Binding (recruitment) of associated with qutenza
1) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.58 Pain Relevance 0.86
Our results are consistent with previous studies in that proliferative responses are primarily mediated by E2F1, E2F2 and E2F3, whereas the recruitment of E2F4 on the promoters suppresses cell proliferation [31], [32], [38].
E2F4 Binding (recruitment) of
2) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.66 Pain Relevance 0.32
Furthermore, the enhanced binding of E2F4 was accompanied by recruitment of the E2F4-binding partner p130 on the cyclin E, TS, cdc25A and cdc6 promoters in capsaicin-treated cells.
E2F4 Binding (binding) of associated with qutenza
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.13 Pain Relevance 0.45

General Comments

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